Effect of morphine sulphate on histopathologic changes in lung tissue after ischemia reperfusion injury [İskemi reperfüzyon hasari sonrasinda akciğer dokusunda meydana gelen histopatolojik değişiklikler üzerinde morfin sulfatin etkisi]

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dc.contributor.authorDüzgün N.
dc.contributor.authorEsme H.
dc.contributor.authorKarabağli P.
dc.contributor.authorİyisoy M.S.
dc.contributor.authorDuran M.
dc.date.accessioned2020-03-26T19:43:34Z
dc.date.available2020-03-26T19:43:34Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Endogenous opioids play an important role in tolerance to ischaemia at cellular level. We aimed to investigate the effect of morphine sulphate on the histopathologic changes in the lung tissue after ischemia reperfusion injury. Material and Methods: Forty female Wistar Albino rats were used in the study. The subjects were divided into 4 groups. İschemia reperfusion (IR) group; thoracotomy was performed from the fifth left intercostal space and ischemia reperfusion injury was established. İschemia reperfusion and ischemic postconditioning (IRPC) group; thoracotomy, ischemia reperfusion and postcondutioning. IRPC3 and IRPC30 groups; in addition to IRPC group, 3 and 30 ?mol morphine sulphate were administered. In the histopathological examination of lung tissue, neutrophile count, congestion, interstitial edema, tissue damage, and VEGF (Vascular endothelial growth factor) and EGFR (Epidermal growth factor receptor) positively stained cells were evaluated semi quantitatively. Results: In the histopathological analysis there was a statistically significant difference between the IR with IRAK (P<0.01), IRAK3 (P<0.01), and IRAK30 (P<0.01) groups in terms of neutrophile count and congestion edema scores. There was a statistically significant difference between the IR with IRAK (P<0.01) and IRAK3 (P<0.01) groups and IRAK with IRAK30 (P<0.05) groups in terms of tissue damage score. Moreover there was a statistically significant difference between the IR and IRAK3 (P<0.01) and IRAK30 (P<0.01) groups in the histopathological analysis in terms of VEGF (+) and EGFR (+) staining cell scores. Conclusion: As a result, ischemic postconditioning and administration of morphine sulphate were applied in the ischemic reperfusion period and histopathologic evaluation was performed. It has been determined that administration of morphine sulphate in the prevention of ischemia reperfusion injury is a more effective method than ischemic postconditioning. © 2017 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2017-55295en_US
dc.identifier.endpage79en_US
dc.identifier.issn1300-0292en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://dx.doi.org/10.5336/medsci.2017-55295
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35706
dc.identifier.volume37en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMorphineen_US
dc.subjectPathologyen_US
dc.subjectReperfusion injuryen_US
dc.titleEffect of morphine sulphate on histopathologic changes in lung tissue after ischemia reperfusion injury [İskemi reperfüzyon hasari sonrasinda akciğer dokusunda meydana gelen histopatolojik değişiklikler üzerinde morfin sulfatin etkisi]en_US
dc.typeArticleen_US

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