Innovative perspectives on Pulicaria dysenterica extracts: phyto-pharmaceutical properties, chemical characterization and multivariate analysis

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dc.contributor.authorde la Luz Cadiz-Gurrea, Maria
dc.contributor.authorZengin, Gökhan
dc.contributor.authorKayacık, Özlem
dc.contributor.authorLobine, Devina
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorJavier Leyva-Jimenez, Francisco
dc.contributor.authorSegura-Carretero, Antonio
dc.date.accessioned2020-03-26T20:14:46Z
dc.date.available2020-03-26T20:14:46Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractBACKGROUND In this study, we aimed to evaluate the influence of different extraction procedures [decoction, homogenizer-assisted extraction (HAE), infusion, maceration, Soxhlet and ultrasound-assisted extraction (UAE)] on the chemical profiling and biological properties of methanol and water extracts of Pulicaria dysenterica (L.) Bernh. The chemical profiles of the extracts were evaluated by high-performance liquid chromatography coupled to electrospray ionization and time-of-flight mass spectrometry (HPLC-ESI-TOF-MS). The antioxidant properties and enzymes (lipase, alpha-amylase, alpha-glucosidase, tyrosinase and cholinesterases) inhibitory potential of the extracts were evaluated. RESULTS The chemical profiles were dependent on the type of extraction methods as well as on the type of solvent. The methanolic extracts showed higher levels of total phenolic, flavonoid, and phenolic acid content, while the highest total flavonol content was observed in the HAE-water extract. Forty different compounds were identified from P. dysenterica. In relation to the potential in vitro anti-diabetic effects, the highest activity against the studied key enzymes was observed for the macerated extract (alpha-amylase: 0.58 +/- 0.03 and alpha- glucosidase: 1.65 +/- 0.03 mmol ACAE g(-1)). The HAE-methanol extract was the most potent inhibitor of cholisterases, whereas the highest activities against tyrosinase were observed for UAE-methanol extract, followed by macerated and Soxhlet. The inhibitory activity of the studied extracts against lipase were in the order: soxhlet > macerated> HAE-methanol > UAE-methanol. CONCLUSION This study has established scientific baseline data on the therapeutic properties of P. dysentrica, thereby advocating the need for further investigations in an endeavour to develop novel pharmaceuticals from this plant. (c) 2019 Society of Chemical Industryen_US
dc.identifier.citationde la Luz Cádiz‐Gurrea, M., Zengin, G., Kayacık, O., Lobine, D., Mahomoodally, M. F., Leyva‐Jiménez, F. J., Segura‐Carretero, A. (2019). Innovative Perspectives On Pulicaria Dysenterica Extracts: Phyto‐Pharmaceutical Properties, Chemical Characterization And Multivariate Analysis. Journal Of The Science Of Food And Agriculture, 99,(13), 6001-6010.
dc.identifier.doi10.1002/jsfa.9875en_US
dc.identifier.endpage6010en_US
dc.identifier.issn0022-5142en_US
dc.identifier.issn1097-0010en_US
dc.identifier.issue13en_US
dc.identifier.pmid31225640en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6001en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jsfa.9875
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37933
dc.identifier.volume99en_US
dc.identifier.wosWOS:000478263400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectextractionen_US
dc.subjectdiabetesen_US
dc.subjectphytomedicinesen_US
dc.subjectmultivariate componenten_US
dc.subjectHPLC-MSen_US
dc.subjectantioxidanten_US
dc.titleInnovative perspectives on Pulicaria dysenterica extracts: phyto-pharmaceutical properties, chemical characterization and multivariate analysisen_US
dc.typeArticleen_US

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