Hepatoprotective effects of coriandrum sativum essential oil against acute hepatotoxicity induced by carbon tetrachloride on rats

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dc.contributor.authorÖzbek H.
dc.contributor.authorKırmızı N.İ.
dc.contributor.authorCengiz N.
dc.contributor.authorErdoğan E.
dc.date.accessioned2020-03-26T19:32:00Z
dc.date.available2020-03-26T19:32:00Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate effect of Coriandrum sativum (CS) essential oil in rat model of carbon tetrachloride (CCl4) induced liver toxicity. Experimental groups were formed as follows: isotonic saline solution (ISS), silibinin, CS-1 (0,3ml/ kg), CS-2 (0,6 ml/kg). Agents were administered intraperitoneally. Blood and liver tissues were collected at the end of the study ended. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured. Liver tissues were evaluated histopathologically. One-way analysis of variance (ANOVA) was used for statistical analyses.As a result silibinin and CS-2 decreased blood AST and ALT levels of their groups and these biochemical results were supported by histopathological results. In conclusion this study has provided evidence that Coriandrum sativum essential oil has significant hepatoprotective effect on carbon tetrachloride induced liver toxicity in rats. © 2016, University of Istanbul. All rights reserved.en_US
dc.identifier.doi10.23893/1307-2080.APS.0543en_US
dc.identifier.endpage40en_US
dc.identifier.issn1307-2080en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0543
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34282
dc.identifier.volume54en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Istanbulen_US
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectCoriandrum sativumen_US
dc.subjectEssential oilen_US
dc.subjectHepatoprotective activityen_US
dc.subjectRatsen_US
dc.titleHepatoprotective effects of coriandrum sativum essential oil against acute hepatotoxicity induced by carbon tetrachloride on ratsen_US
dc.typeArticleen_US

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