Potential neoplastic effects of parathion-methyl on rat liver

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dc.contributor.authorCoral, M. Nisa Unaldi
dc.contributor.authorUcman, Sonay
dc.contributor.authorYildiz, Hasan
dc.contributor.authorOztas, Haydar
dc.contributor.authorDalkilic, Semih
dc.date.accessioned2020-03-26T17:39:42Z
dc.date.available2020-03-26T17:39:42Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic.en_US
dc.description.sponsorshipMustafa Kemal UniversityMustafa Kemal University; Natural and Applied Sciences Instituteen_US
dc.description.sponsorshipThis study was supported by Mustafa Kemal University, Natural and Applied Sciences Institute.en_US
dc.identifier.doi10.1016/S1001-0742(08)62326-8en_US
dc.identifier.endpage699en_US
dc.identifier.issn1001-0742en_US
dc.identifier.issn1878-7320en_US
dc.identifier.issue5en_US
dc.identifier.pmid20108674en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage696en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S1001-0742(08)62326-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23773
dc.identifier.volume21en_US
dc.identifier.wosWOS:000266020800020en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSCIENCE PRESSen_US
dc.relation.ispartofJOURNAL OF ENVIRONMENTAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectatypical acinar cell focusesen_US
dc.subjectAmes testen_US
dc.subjectcarcinogenesisen_US
dc.subjectparathion-methylen_US
dc.titlePotential neoplastic effects of parathion-methyl on rat liveren_US
dc.typeArticleen_US

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