INVESTIGATION OF THE RELATIONSHIPS OF OBESITY WITH MELATONIN AND DEHYDROEPIANDROSTERONE LEVELS

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dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorGokce, Seyid
dc.contributor.authorKurban, Sevil
dc.contributor.authorGokce, Recep
dc.contributor.authorAtalar, Mehmet Nuri
dc.contributor.authorCelik, Muhammed
dc.date.accessioned2020-03-26T19:41:57Z
dc.date.available2020-03-26T19:41:57Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Melatonin is synthesized in pineal gland and plays a role in energy metabolism and the weight-reducing effects. Dehydroepiandrosterone (DHEA) is synthesized primarily by the zona reticularis of adrenal cortex and to a lesser degree by the gonads. DHEA has antioxidant, antilipidperoxidative, antiinflammatory, antiatherogenic, antiaging and weight-reducing or preventing effects. Our aim of this study was to investiagate blood DHEA, melatonin, insulin resistance (IR) and lipids levels and correlations between them in obese and nonobese subjects. Material and Method: The study was performed on 33 obese subjects ((16 male (M), 17 female (F)) aged 40.03 +/- 8.47 years and 33 normal weight healty controls (15M, 18F) aged 28.76 +/- 6.22 years. In both groups, DHEA, melatonin, IR, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol and triglyceride levels and correlations between them were investigated. DHEA and melatonin levels were determined by ELISA method and insulin, fasting blood glucose levels and lipid parameters were determined by rutin method using commercially avilable kits. IR was calculated using a formula. Results: There was no statistically significant differences between DHEA and melatonin levels of the groups and there were no correlations between them in both groups. However, there was a significant negative correlation between DHEA and triglyceride levels in the obese group (r=-0.342, p<0.05). Conclusion: Our results show that DHEA and melatonin levels were not changed in obesity and they have no effects on IR. However significant negative correlation between DHEA and triglyceride levels in obese subjects needs to be more investigated in terms of the effect of DHEA on adipose tissue and obesity.en_US
dc.identifier.endpage75en_US
dc.identifier.issn1305-2381en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage70en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35232
dc.identifier.volume13en_US
dc.identifier.wosWOS:000416078300011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherNOBEL ILACen_US
dc.relation.ispartofNOBEL MEDICUSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectObesityen_US
dc.subjectDHEAen_US
dc.subjectmelatoninen_US
dc.subjectinsulin resistanceen_US
dc.subjectblood lipidsen_US
dc.titleINVESTIGATION OF THE RELATIONSHIPS OF OBESITY WITH MELATONIN AND DEHYDROEPIANDROSTERONE LEVELSen_US
dc.typeArticleen_US

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