Improved Anticancer Efficacy of p-tert-butylcalix[4]arene through Surface Modifications

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dc.contributor.authorArpacı, Pembegül Uyar
dc.contributor.authorÖzcan, Fatih
dc.contributor.authorGök, Emine
dc.contributor.authorErtul, Şeref
dc.date.accessioned2020-03-26T19:41:52Z
dc.date.available2020-03-26T19:41:52Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description7th IEEE International Conference Nanomaterials - Application and Properties (NAP) -- SEP 10-15, 2017 -- Odessa, UKRAINEen_US
dc.description.abstractThe search for new potent anticancer drugs that can only target cancer cells, rather than affecting normal tissues is very much commendable. Supramolecular Calixarene (p-tert-butylcalix[4]arene) is a highly promising candidate in this regard and could be modified to enhance preferential cytotoxicity for targeted therapy. Calixarenes are a family of bowl or cone shaped synthetic supramolecular macrocycles, composed of phenol units linked by methylene bridges through and an aldehyde. The proliferation rate of L-929 were observed higher than MCF-7 cells in the Real-Time Cell Analysis (RTCA) Systems. Our research directs that calixarene shows effective preferential cytotoxicity at a concentration range of 25 to 100 mu g/mL with enhanced preferential cytotoxicity shown by the modification of pyridinium group at the position 3 against MCF-7 breast cancer cells. In this present study, the effect of surface altered calixarene by pyridinium groups on preferential cytotoxicity in cancer cell in-vitro by comparing with innate preferential toxicity shown by unaltered. The results reported in this study demonstrated that tumor-preferential in-vitro cytotoxicity of p-tert-butylcalix[4] arene against MCF-7 over L-929 cells present a promising approach for efficient and safe cancer therapy.en_US
dc.description.sponsorshipIEEE, Minist Educ Sci Ukraineen_US
dc.identifier.isbn978-1-5386-2810-2
dc.identifier.issn2306-580Xen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35188
dc.identifier.wosWOS:000426973100163en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.relation.ispartofPROCEEDINGS OF THE 2017 IEEE 7TH INTERNATIONAL CONFERENCE NANOMATERIALS: APPLICATION & PROPERTIES (NAP)en_US
dc.relation.ispartofseriesProceedings of the international conference Nanomaterials-Applications and properties
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalixareneen_US
dc.subjectSurface Funtionalizationen_US
dc.subjectCytotoxicityen_US
dc.subjectMCF-7en_US
dc.titleImproved Anticancer Efficacy of p-tert-butylcalix[4]arene through Surface Modificationsen_US
dc.typeConference Objecten_US

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