The Maternal and Neonatal Effects of Intrathecal Sufentanil and Fentanyl Added to Hyperbaric Bupivacaine for Cesarean Section [Sezaryenlerde Bupivakaine Eklenen Sufentanil ve Fentanilin Maternal ve Neonatal Etkileri]

We aimed to evaluate the maternal and neonatal effects of intrathecal sufentanil, fentanyl and plasebo added to hyperbaric bupivacaine for cesarean section. After etthical committee approval, 45 healty, full-term parturients allocated into three groups. Group K (control group) received 10 mg bupivacaine heavy and 2 cc % 0.9 NaCl, Group F received 10 mg bupivacaine heavy and 25 ?g fentanyl and Group S received 10 mg bupivacaine heavy and 10 pg sufentanil intrathecally, Total volume of 4 mL was used in both groups. Haemodynamic values, sensory and motor blocs, the first requirement time for analgesia and Intrapostoperative side effects were recorded. Blood samples were collected from the umblical artery for blood gas analyses. Apgar score at 1 and 5 min. and Neurologic and Adaptive Capacity Score (NACS) of newborns at 2 evaluated. There were no significant differences in patients characteristics, time to reach L1-2, T10 and maximal sensory level, degree and resolution of motor block, blood gas analyses, Apgar and NACS scores. Nausea was more in group K than in group S and F (p<0.05). Pruritus was a frequent side effect both in group S and F (p<0.05), but it was more remarkable in group S (p<0.05). Complete analgesia was prolong in group F and S than in group K. The first requirement time for analgesia was longer in group S compared to group F (p<0.05). In summary, intrathecal fentanyl 25 pg or sufentanil 10 ?g added to hyperbaric bupivacaine for cesarean section reduced nausea and increased the duration of analgesia in the early postoperative period. Because this combinations had no adverse effects oil neonatals we concluded that they can be used safely in cesarean sections.