Vaginal high dose rate brachytherapy alone in patients with intermediate- to high-risk stage I endometrial carcinoma after radical surgery

Basit Öğe Kaydı
dc.contributor.authorAtahan, I. L.
dc.contributor.authorOzyar, E.
dc.contributor.authorYildiz, F.
dc.contributor.authorOzyigit, G.
dc.contributor.authorGenc, M.
dc.contributor.authorUlger, S.
dc.contributor.authorUsubutun, A.
dc.date.accessioned2020-03-26T17:28:26Z
dc.date.available2020-03-26T17:28:26Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe objective of this study was to analyze the efficacy and morbidity of vaginal cuff brachytherapy alone in intermediate- to high-risk stage I endometrial cancer patients after complete surgical staging. Between October 1994 and November 2005, 128 patients with intermediate- to high-risk stage I endometrial adenocarcinoma were treated with high dose rate (HDR) brachytherapy alone after complete surgical staging. The intermediate- to high-risk group was defined as any stage I with grade 3 histology or stage IB grade 2 or any stage IC disease. The comprehensive surgery was in the form of total abdominal hysterectomy, bilateral salpingo-oophorectomy in addition to infracolic omentectomy, and routine pelvic and para-aortic lymphadenectomy. The median number of the lymph nodes dissected was 33. The median age at the time of diagnosis was 60 years. Forty patients were staged as IB (grade 2: 25 and grade 3: 15), and 88 patients were staged as IC (grade 1: 31, grade 2: 41, and grade 3: 16). A total dose of 27.5 Gy with HDR brachytherapy, prescribed at 0.5 cm, was delivered in five fractions in 5 consecutive days. Median follow-up was 48 months. Six (4.7%) patients developed either local recurrence (n = 2) or distant metastases (n = 4). Five-year overall survival and disease-free survival (DFS) rates are 96% and 93%, respectively. Only age was found to be significant prognostic factor for DFS. Patients younger than 60 years have significantly higher DFS (P = 0.006). None of the patients experienced grade 3/4 complications due to the vaginal HDR brachytherapy. Vaginal cuff brachytherapy alone is an adequate treatment modality in stage I endometrial adenocarcinoma patients with intermediate- to high-risk features after complete surgical staging with low complication rates.en_US
dc.identifier.doi10.1111/j.1525-1438.2008.01198.xen_US
dc.identifier.endpage1299en_US
dc.identifier.issn1048-891Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid18284452en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1294en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1525-1438.2008.01198.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22780
dc.identifier.volume18en_US
dc.identifier.wosWOS:000260823500018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectendometrial canceren_US
dc.subjectradiotherapyen_US
dc.subjectstage Ien_US
dc.titleVaginal high dose rate brachytherapy alone in patients with intermediate- to high-risk stage I endometrial carcinoma after radical surgeryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu