Paeonia arietina and Paeonia kesrounansis bioactive constituents: NMR, LC-DAD-MS fingerprinting and in vitro assays

Basit Öğe Kaydı
dc.contributor.authorSut, Stefania
dc.contributor.authorZengin, Gökhan
dc.contributor.authorDall'Acqua, Stefano
dc.contributor.authorGazdova, Marketa
dc.contributor.authorSmejkal, Karel
dc.contributor.authorBulut, Gizem
dc.contributor.authorDoğan, Ahmet
dc.contributor.authorHaznedaroğlu, Mehmet Zeki
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorMaggi, Filippo
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:19:06Z
dc.date.available2020-03-26T20:19:06Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractPaeonia species have been valued for their ethnomedicinal uses in various countries and received much interest among the scientific community for their therapeutic properties, including anti-microbial, anti-inflammatory, anti-cancer, nephroprotective and hepatoprotective effects. The multiple phytother-apeutical applications of Paeonia species inspired us to establish the phytochemical fingerprint and to evaluate the biological properties of ethyl acetate, methanol, and aqueous extracts from the roots and aerial parts of two Paeonia species (P. arietina G. Anderson and P. kesrounansis Thiebaut). Phytoconstituents of P. arietina and P. kesrounansis extracts were analyzed using 1D and 2D NMR and LC-DAD-ESI-MS. The total content of phenolics (TPC) and flavonoids (TFC) in the extracts was also evaluated. The antioxidant activity was profiled using DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelation assays. Enzyme inhibitory properties were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, alpha-amylase, and alpha-glucosidase. Phytochemical analysis of P. arietina and P. kesrounansis extracts showed the presence of galloyl esters of sugars, galloyl monoterpenes, and glycosylated flavonoids. The three solvent extracts presented different behavior in the bioassays. The highest antioxidant activity, tyrosinase and AChE inhibition were observed for the methanolic extract of the aerial parts of P. kesrounansis. In addition, the ethyl acetate extracts of the aerial parts of both plants were the most effective inhibitors of alpha-amylase. The highest BChE inhibition was observed for root methanolic extract of P. kesrounansis while the root ethyl acetate extract of P. arietina exerted the strongest inhibition of alpha-glucosidase. Methanol extract of P. kesrounansis aerial parts presented the highest TPC, while TFC was greatest in the corresponding extract of P. arietina. Our findings can be considered as a starting point for future studies to further validate the effectiveness and safety profiles of these plants in folk medicine. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipIGA UVPS Brno [310/2016/FaF]en_US
dc.description.sponsorshipThis work was supported by the IGA UVPS Brno (grant no. 310/2016/FaF)en_US
dc.identifier.citationSut, S., Zengin, G., Dall’Acqua, S., Gazdová, M., Šmejkal, K., Bulut, G., Dogan, A., Haznedaroglu, M. Z., Aumeeruddy, M. Z., Maggi, F., Mahomoodally, M. F. (2019). Paeonia Arietina And Paeonia Kesrounansis Bioactive Constituents: NMR, LC-DAD-MS Fingerprinting And İn Vitro Assays. Journal Of Pharmaceutical And Biomedical Analysis, 165, 1-11.
dc.identifier.doi10.1016/j.jpba.2018.11.040en_US
dc.identifier.endpage11en_US
dc.identifier.issn0731-7085en_US
dc.identifier.issn1873-264Xen_US
dc.identifier.pmid30481579en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpba.2018.11.040
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38065
dc.identifier.volume165en_US
dc.identifier.wosWOS:000456899500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPaeonia arietinaen_US
dc.subjectPaeonia kesrounansisen_US
dc.subjectAntioxidanten_US
dc.subjectCholinesteraseen_US
dc.subjectTyrosinaseen_US
dc.subjectalpha-Glucosidaseen_US
dc.subjectalpha-Amylaseen_US
dc.titlePaeonia arietina and Paeonia kesrounansis bioactive constituents: NMR, LC-DAD-MS fingerprinting and in vitro assaysen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Gökhan zengin4.pdf
Boyut:
2.55 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyoloji/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu