Autoimmune hepatitis-primary biliary cirrhosis overlap syndrome concomitant with immune hemolytic anemia and immune thrombocytopenic purpura (Evans syndrome)

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dc.contributor.authorKorkmaz, Huseyin
dc.contributor.authorBugdaci, Mehmet Sait
dc.contributor.authorTemel, Tuncer
dc.contributor.authorDagli, Mehmet
dc.contributor.authorKarabagli, Pinar
dc.date.accessioned2020-03-26T18:41:11Z
dc.date.available2020-03-26T18:41:11Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAutoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) associated with Evans syndrome; combination of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP) has rarely been reported. We report the case of a 53-year-old patient who presented with weakness, myalgia, arthralgia, shortness of breath and purpura. Initial laboratory investigations revealed liver dysfunction, anemia and thrombocytopenia. Anti-nuclear (ANA) and antimitochondrial M2 (AMA M2) antibodies were positive. Diagnose of PBC-AIH overlap was made by clinical, serological and histological investigations. AIHA and ITP was identified with clinical-laboratory findings and bone marrow puncture. She was treated with IVIG followed by prednisolone and ursodeoxycholic acid. Hemoglobin-thrombocytes increased rapidly and transaminases improved at day 8. We have reported the first case in the literature with AIH-PBC overlap syndrome concurrent by ITP and AIHA which suggest the presence of shared genetic susceptibility factors in multiple autoimmune conditions including AIH, PBC, ITP and AIHA. (C) 2012 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinre.2012.11.001en_US
dc.identifier.endpageE50en_US
dc.identifier.issn2210-7401en_US
dc.identifier.issn2210-741Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid23273499en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE45en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.clinre.2012.11.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29256
dc.identifier.volume37en_US
dc.identifier.wosWOS:000325618200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER MASSON, CORPORATION OFFICEen_US
dc.relation.ispartofCLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleAutoimmune hepatitis-primary biliary cirrhosis overlap syndrome concomitant with immune hemolytic anemia and immune thrombocytopenic purpura (Evans syndrome)en_US
dc.typeArticleen_US

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