Soluble CD40 Ligand, High Sensitive C-Reactive Protein and Fetuin-A Levels in Patients with Essential Thrombocythemia

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dc.contributor.authorBilgir, Ferda
dc.contributor.authorBilgir, Oktay
dc.contributor.authorKebapçılar, Levent
dc.contributor.authorÇalan, Mehmet
dc.contributor.authorÖzdemirkıran, Füsun
dc.contributor.authorCinali, Türker
dc.contributor.authorBozkaya, Giray
dc.date.accessioned2020-03-26T18:31:20Z
dc.date.available2020-03-26T18:31:20Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: CD40 ligand (CD40L) is expressed on the surface of activated platelets and activated T lymphocytes. Circulating soluble CD40 ligand (sCD40L) is formed from these molecules proteolytically. Fetuin-A is a potent antiinflammatory cytokine. Aim of the study: In this study, we aim to investigate sCD40L levels to determine whether there is platelet activation and to measure high sensitive C-reactive protein (hs-CRP) levels to demonstrate if this leads to an inflammatory process and also to study fetuin-A levels to see if there is any concomitant antiinflammatory event in patients with essential thrombocythemia (ET). Methods: We compared 30 patients with essential thrombocythemia with 30 control subjects and in these patients we measured levels of sCD40L, hs-CRP and fetuin-A. Results: sCD40L levels were significantly higher in the Er group compared to the control group (30.6 +/- 14.4 vs. 18.5 +/- 8.9, p = 0.001). Although fetuin-A levels showed a slight trend to be increased in ET patients, the difference did not reach significance (4.5 +/- 4.2 vs. 3.2 +/- 2.1, p = 0.158). There were no statistically significant differences in hs-CRP levels (24.6 +/- 4.9 vs. 25.0 +/- 5.2, p = 0.750). Conclusion: sCD40L was significantly higher in patients with an ET without any association with an inflammatory process and we believe this may be a marker of platelet regeneration.en_US
dc.identifier.citationBilgir, F., Bilgir, O., Kebapçılar, L., Çalan, M., Özdemirkıran, F., Cinali, T., Bozkaya, G., (2012). Soluble CD40 Ligand, High Sensitive C-Reactive Protein and Fetuin-A Levels in Patients with Essential Thrombocythemia. Transfusion and Apheresis Science, 46, 67-71. Doi:10.1016/j.transci.2011.11.013
dc.identifier.doi10.1016/j.transci.2011.11.013en_US
dc.identifier.endpage71en_US
dc.identifier.issn1473-0502en_US
dc.identifier.pmid22196954en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.transci.2011.11.013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28411
dc.identifier.volume46en_US
dc.identifier.wosWOS:000301812200015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKebapçılar, Levent
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsCD40Len_US
dc.subjectHigh sensitive C-reactive protein (hs-CRP)en_US
dc.subjectFetuin-Aen_US
dc.subjectEssential thrombocythemiaen_US
dc.titleSoluble CD40 Ligand, High Sensitive C-Reactive Protein and Fetuin-A Levels in Patients with Essential Thrombocythemiaen_US
dc.typeArticleen_US

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