3 ',4 '-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia

Basit Öğe Kaydı
dc.contributor.authorÖz, Mehmet
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorÇalışkan, Merve
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.date.accessioned2020-03-26T19:33:22Z
dc.date.available2020-03-26T19:33:22Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: In the present study, effects of 3', 4'-dihydroxyflavonol (DiOHF) on anxiety-like behavior, and learning and memory were investigated in a model of transient global cerebral ischemia and reperfusion. Methods: The animals were assigned to sham-operated, ischemia, and two DiOHF-treated (10 mg/kg i. p.) groups. DiOHF was administered at 1 hour before and immediately after the ischemia. Male rats were subjected to bilateral common carotid artery occlusion to induce acute cerebral ischemia for 20 minutes, followed by reperfusion for 7 days. The openfield, elevated plus maze (EPM), and Morris water maze tests were used to evaluate the effects of DiOHF treatment on ischemia-induced locomotor activity, anxiety-like behavior, and spatial and recognition memory impairments, respectively. Results: In the open field test, locomotor activity in the ischemic rats was not altered 6 days after the ischemia, nor was anxiety-like behavior, which was evaluated with the EPM (P > 0.05). In the water-maze test, cerebral ischemia significantly decreased the exploration time in the target quadrant, and the platform crossing counts were lower (P < 0.05) in the probe trial test; this memory impairment was significantly improved by DiOHF applied 1 hour before and immediately after ischemia (P < 0.05). Discussion: All together, these findings suggest that DiOHF reverses spatial learning and memory deficits resulting from transient global ischemia but has no significant effect on anxiety-like behavior.en_US
dc.identifier.doi10.1179/1476830514Y.0000000159en_US
dc.identifier.endpage126en_US
dc.identifier.issn1028-415Xen_US
dc.identifier.issn1476-8305en_US
dc.identifier.issue2en_US
dc.identifier.pmid25290491en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://dx.doi.org/10.1179/1476830514Y.0000000159
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34702
dc.identifier.volume20en_US
dc.identifier.wosWOS:000399670000005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNUTRITIONAL NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiOHFen_US
dc.subjectStrokeen_US
dc.subjectLearning and memoryen_US
dc.subjectAnxiety-like behavioren_US
dc.title3 ',4 '-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemiaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu