Side effect of metenolone enanthate on rats heart in puberty: Morphometrical study

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dc.contributor.authorOzdemir, Ozgur
dc.contributor.authorBozkurt, Ibrahim
dc.contributor.authorOzdemir, Mehmet
dc.contributor.authorYavuz, Orhan
dc.date.accessioned2020-03-26T18:43:21Z
dc.date.available2020-03-26T18:43:21Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was the investigation of effects of the metenolone enanthate (ME) that is used among athletes as doping and muscle amplifier, on hearts of male and female rats that are in puberty using morphometrical methods. A total of 36 rats which were divided into three separate groups (Experiment, ME; vehicle, PO; control, C) each consisting of 6 male and 6 female rats were used. 0.5 mg/kg metenolone enanthate was applied intraperitoneally into experiment subjects 5 times a week over a period of 4 weeks. At the end of experiment, rats were euthanized and their hearts were cut at the level of musculus papillaris after the fixation in formalin. Hearts were taken out and embedded in paraffin wax. Photos were taken at cut surfaces, and thickness, diameters and surface area levels were measured. Left ventriculus mass (LVM) and left ventriculus mass index (LVMI) were calculated. In the study LVM (p < 0.005) and LVMI (p < 0.05) were found to be significantly higher in the ME group in females whereas left ventricular lumen diameter (LVLD) were found to be significantly lower (p < 0.05). Thus left ventricular hypertrophy development was observed. LVM and LVMI were found to be similar in ME and C groups among male rats and the highest level of these data were found in the group. LVM and LVMI were higher among females (p < 0.006). In conclusion, it has been shown that the adverse effects of ME on heart were developing starting from puberty and resulting with the enlargement of the heart and left ventricular hypertrophy and especially among females this condition was more evident. It has also been discussed that the continuous use of drugs may further enhance this condition. (c) 2012 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.etp.2012.09.009en_US
dc.identifier.endpage750en_US
dc.identifier.issn0940-2993en_US
dc.identifier.issn1618-1433en_US
dc.identifier.issue6en_US
dc.identifier.pmid23280519en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage745en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.etp.2012.09.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29815
dc.identifier.volume65en_US
dc.identifier.wosWOS:000322929800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAGen_US
dc.relation.ispartofEXPERIMENTAL AND TOXICOLOGIC PATHOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAASen_US
dc.subjectMetenolone enanthateen_US
dc.subjectHearten_US
dc.subjectRaten_US
dc.subjectLeft ventricular hypertrophyen_US
dc.titleSide effect of metenolone enanthate on rats heart in puberty: Morphometrical studyen_US
dc.typeArticleen_US

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