PATHOLOGICAL CHANGES IN THE ACUTE PHASE OF STREPTOZOTOCIN-INDUCED DIABETIC RATS

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dc.contributor.authorÖzdemir, Özgür
dc.contributor.authorAkalın, Pınar Peker
dc.contributor.authorBaşpınar, Nuri
dc.contributor.authorHatipoğlu, Fatih
dc.date.accessioned2020-03-26T17:39:34Z
dc.date.available2020-03-26T17:39:34Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aimed at investigating the acute phase of pathological changes in streptozotocin-induced diabetic rats with varying glucose levels. Eighteen rats, six control, six D1 group (with glucose level of 200-300 mg/dl), and six D2 group (with glucose level over 300 mg/dl), were used. They were euthanasied on the 14(th) after streptozotocin administration. Samples taken from internal organs were examined under a light microscope after routine histopathology processes. The changes in the organs were scored as light, mild and severe. The glomerulus, Bowman's space, and renal corpuscle areas were calculated. There were significant differences between THE diabetic groups and control in terms of degenerative lesions in the pancreas, liver, spleen, and kidneys. It was found that increasing the area of Bowman's space was directly proportional to blood glucose level. There was a significant difference between D1 and D2 in terms of the number of apoptotic cells in the spleen and there was an increase in apoptosis. It was concluded that the increased width of the Bowman's space in the acute phase of type-I diabetes, and the changes observed in the other organs, would be useful for further studies on diabetes.en_US
dc.identifier.endpage790en_US
dc.identifier.issn0042-4870en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage783en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23746
dc.identifier.volume53en_US
dc.identifier.wosWOS:000277071400040en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNATL VETERINARY RESEARCH INSTen_US
dc.relation.ispartofBULLETIN OF THE VETERINARY INSTITUTE IN PULAWYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectraten_US
dc.subjectstreptozotocinen_US
dc.subjectdiabetes mellitusen_US
dc.subjectacute phaseen_US
dc.subjectpathologyen_US
dc.titlePATHOLOGICAL CHANGES IN THE ACUTE PHASE OF STREPTOZOTOCIN-INDUCED DIABETIC RATSen_US
dc.typeArticleen_US

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