Influences of Hypertonic and Hypovolemic Treatments on Vasopressin Response in Propylthiouracil (PTU) Induced Hypothyroid Rat and Effect on Supplementation With L-Thyroxine

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dc.contributor.authorAydın, Leyla
dc.contributor.authorMoğulkoç, R.
dc.contributor.authorBaltacı, A. K.
dc.date.accessioned2020-03-26T17:49:11Z
dc.date.available2020-03-26T17:49:11Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was performed to investigate the effects of L-thyroxine treatment on plasma vasopressin (AVP) levels in rats with hypothyroidism induced by propylthiouracil (PTU). Animals were separated into three groups each having 6 rats: control, PTU, PTU+L-thyroxine groups. Then, the groups were further divided into 3 sub-groups including 6 rats ( a; basal, b; hypertonic stimulated and c; hypovolemic stimulated). At the end of the experiments all rats were decapitated in order to obtain plasma samples for analysis in terms of Hct, osmolality, TT3, TT4 and vasopressin. Haematocrit (Hct) levels were the highest in hypovolemic stimulated sub-group (P < 0.001). Osmolality levels were higher in hypertonic stimulated sub-groups ( P < 0.001). Total T-3 and T-4 values were the lowest in the PTU group and the highest in the L-thyroxine treated group (P < 0.001). Plasma AVP levels were reduced by hypothyroidism. However, L-thyroxine treatment after the hypothyroidism prevented this reduction ( P < 0.001). Vasopressin responses to basal, hypovolemic and hypertonic stimulations were the lowest in the PTU group (P < 0.001). The results of the present study show that basal and stimulated plasma vasopressin levels are reduced in PTU-induced hypothyroidism. However, L-thyroxine treatment following hypothyroidism prevents this reduction.en_US
dc.identifier.citationAydın, L., Moğulkoç, R., Baltacı, A. K., (2010). Influences of Hypertonic and Hypovolemic Treatments on Vasopressin Response in Propylthiouracil (PTU) Induced Hypothyroid Rat and Effect on Supplementation With L-Thyroxine. Acta Biologica Hungarica, 61(1), 1-9. Doi: 10.1556/ABiol.61.2010.1.1
dc.identifier.doi10.1556/ABiol.61.2010.1.1en_US
dc.identifier.endpage9en_US
dc.identifier.issn0236-5383en_US
dc.identifier.issn1588-256Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid20194094en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1556/ABiol.61.2010.1.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25002
dc.identifier.volume61en_US
dc.identifier.wosWOS:000275055000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAydın, Leyla
dc.institutionauthorMoğulkoç, R.
dc.institutionauthorBaltacı, A. K.
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Biologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHypothyroidismen_US
dc.subjectThyroxine treatmenten_US
dc.subjectAvpen_US
dc.subjectOsmolalityen_US
dc.subjectRaten_US
dc.titleInfluences of Hypertonic and Hypovolemic Treatments on Vasopressin Response in Propylthiouracil (PTU) Induced Hypothyroid Rat and Effect on Supplementation With L-Thyroxineen_US
dc.typeArticleen_US

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