Pharmacological and polyphenolic profiles of Phyllanthus phillyreifolius var. comrnersonii Mull. Arg: An unexplored endemic species from Mauritius

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dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorYerlikaya, Şerife
dc.contributor.authorLlorent-Martinez, Eulogio J.
dc.contributor.authorUğurlu, Aslı
dc.contributor.authorBaloğlu, Mehmet Cengiz
dc.contributor.authorAltunoğlu, Yasemin Çelik
dc.contributor.authorMollica, Adriano
dc.contributor.authorDardenne, Kurty Kersley
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorPuchooa, Daneshwar
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:19:07Z
dc.date.available2020-03-26T20:19:07Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractPhyllanduts phillyreifolius var. conunersonii Mfill. Arg is an endemic plant of Mauritius. To date, no study has been performed concerning its polyphenolic profile and pharmacological properties. In this study, a decoction (water), ethyl acetate and methanol extracts of the aerial parts of P. phillyreifolius, obtained from different extraction procedures (maceration and Soxhlet), were studied for antibacterial, antioxidant, anticancer, and enzyme inhibitory properties along with their polyphenolic profile. The ethyl acetate macerated extract showed high antibacterial activity against B. cereus (MIC = 0.293 mg/mL) and E. coil (MIC = 0.417 mg/mL) while S. epidermidis was most susceptible to the ethyl acetate-Soxhlet extract (MIC = 0.521 mg/mL). The methanolSoxhlet extract displayed the most potent cupric and ferric reducing power, and metal chelating effect, while the macerated methanolic extract was the most effective DPPH and ABTS scavenger, and BChE inhibitor. Only the ethyl acetate-Soxhlet extract exhibited alpha-glucosidase inhibition. All extracts exhibited a strong anti-tyrosinase activity, which was further investigated by molecular docking and molecular dynamic. After 48 h exposure to the extracts for HeLa cell lines, the ethyl acetate-Soxhlet extract showed the highest inhibition (IC50 = 533.1 pg/mL) while the decoction extract was more cytotoxic to MDA-MB-231 cells (IC50 = 337.4 pg/mL). Treatment of cancer cell lines with all P. phillyreifolius extracts resulted in a time-dependent reduction of cell viability for HeLa and dose-and time-dependent reduction for MDA-MB-231. Gene expression ratio of Bcl-2 to Bax was higher for all Soxhlet-extracts. Total phenolics (TPC) and flavonoids (TFC) content were highest in the decoction and methanol-Soxhlet extract, respectively (122.43 mg GAE/g extract and 31.28 mg RE/g extract, respectively). The extracts were abundant in ellagitannins, although phenolic acids and flavonoids were also detected. Granatin B was detected for the first time in Phyllanthus species. Overall, the aerial parts of P. phillyreifolius exemplify a potent reservoir of bioactive phytochemicals for therapeutic applications.en_US
dc.identifier.citationMahomoodally, M. F., Yerlikaya, S., Llorent-Martínez, E. J., Uğurlu, A., Baloglu, M. C., Altunoglu, Y. C., Mollica, A., Dardenne, K. K., Aumeeruddy, M. Z., Puchooa, D., Zengin, G. (2019). Pharmacological And Polyphenolic Profiles Of Phyllanthus Phillyreifolius Var. Commersonii Müll. Arg: An Unexplored Endemic Species From Mauritius. Food Research International, 115, 425-438.
dc.identifier.doi10.1016/j.foodres.2018.10.075en_US
dc.identifier.endpage438en_US
dc.identifier.issn0963-9969en_US
dc.identifier.issn1873-7145en_US
dc.identifier.pmid30599961en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage425en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.foodres.2018.10.075
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38090
dc.identifier.volume115en_US
dc.identifier.wosWOS:000456758800050en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofFOOD RESEARCH INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPhyllanthus phillyreifoliusen_US
dc.subjectAntibacterialen_US
dc.subjectAnticanceren_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPolyphenolicen_US
dc.titlePharmacological and polyphenolic profiles of Phyllanthus phillyreifolius var. comrnersonii Mull. Arg: An unexplored endemic species from Mauritiusen_US
dc.typeArticleen_US

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