Serum Antioxidant Status and Adenosine Deaminase Activity During the Gestational Period of Sheep

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dc.contributor.authorAydın, İbrahim
dc.contributor.authorBülbül, T.
dc.contributor.authorPolat, Esad Sami
dc.contributor.authorYazar, Enver
dc.date.accessioned2020-03-26T18:04:59Z
dc.date.available2020-03-26T18:04:59Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the serum oxidative status and adenosine deaminase activity during the gestational period in sheep. A total of 16 sheep fed with rations formulated according to the period of gestation were included in this study, and serum samples were obtained at pre-conception (PC). on the 1, 2. 3, and 4 months of pregnancy and on the 5(th) month just after the postpartum (JP) for determining the variations of the malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO), beta-carotene and vitamin A concentrations as well as the enzyme superoxide dismutase (SOD) and adenosine deaminase (ADA) activities with adequate enzyme-linked immunosorbent assays. The MDA and beta-carotene concentrations early and markedly increased during pregnancy while the increase in GSH concentrations was delayed and more progressive and SOD activity weakly varied during pregnancy but reached significantly elevated values just after the postpartum. By contrast. vitamin A and NO concentrations were significantly depressed and the variations of the ADA activity exhibited a bimodal profile with maximal value on the first month and minimal value on the 4(th) month. These results demonstrate the occurrence of an oxidative stress during pregnancy in sheep and that the tissue adenosine contents were sequentially controlled by the important ADA activity fluctuations.en_US
dc.description.abstractL'objectif de cette étude était d'évaluer l'équilibre oxydants / antioxydants dans le sérum ainsi que l’activité de l’adénosine désaminase (ADA) pendant la gestation chez la brebis. Au total, 16 brebis nourries avec des rations adaptées à la période de gestation ont été utilisées et des prélèvements sériques ont été réalisés avant la conception, lors du 1er, 2ème, 3ème et 4ème mois de gestation et au 5ème mois juste après l’agnelage afin de déterminer les concentrations de MDA (malonedialdéhyde), de GSH (glutathion), de NO (oxyde nitreux), de β-carotène et de vitamine A ainsi que les activités sériques de la SOD (superoxyde dismutase) et de l’ADA par des tests immunoenzymatiques adaptés. Les concentrations de MDA et de β-carotènes ont précocement et fortement augmenté pendant la gestation alors que l’augmentation des concentrations de GSH s’est avérée plus tardive et plus progressive et que l’activité de la SOD a très faiblement varié mais a atteint des valeurs significativement élevées juste après le post-partum. En revanche, les concentrations de vitamine A et de NO ont été significativement diminuées et l’activité de l’ADA a varié de façon bimodale avec un maximum le 1er mois et un minimum le 4ème mois. Ces résultats démontrent l’existence d’un stress oxydatif durant la gestation chez la brebis et que les concentrations tissulaires en adénosine sont séquentiellement contrôlées par d’importantes variations de l’activité ADA.
dc.identifier.citationAydın, İ., Bülbül, T., Polat, E. S., Yazar, E., (2010). Serum Antioxidant Status and Adenosine Deaminase Activity During the Gestational Period of Sheep. Revue De Medecine Veterinaire, 161(11), 479-484.
dc.identifier.endpage484en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issn2258-0646en_US
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25255
dc.identifier.volume161en_US
dc.identifier.wosWOS:000286721100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAydın, İbrahim
dc.institutionauthorPolat, Esad Sami
dc.institutionauthorYazar, Enver
dc.language.isoenen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSheepen_US
dc.subjectPregnancyen_US
dc.subjectMalonedialdehydeen_US
dc.subjectAntioxidantsen_US
dc.subjectBeta-caroteneen_US
dc.subjectAdenosine deaminaseen_US
dc.subjectBrebis
dc.subjectGestation
dc.subjectDésaminase
dc.titleSerum Antioxidant Status and Adenosine Deaminase Activity During the Gestational Period of Sheepen_US
dc.title.alternativeStatut Antioxydant Et Activité Adénosine Désaminase Sériques Pendant La Gestation Chez La Brebisen_US
dc.typeArticleen_US

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