Correlation between vaspin and PANSS scores in schizophrenia patients with obesity

Basit Öğe Kaydı
dc.authorid0000-0003-4787-5333
dc.contributor.authorErtekin, Hülya.
dc.contributor.authorUysal, Sema.
dc.contributor.authorAydın, Memduha.
dc.contributor.authorIlhan, Bilge.
dc.contributor.authorErtekin, Yusuf Haydar.
dc.date.accessioned2020-03-26T20:13:11Z
dc.date.available2020-03-26T20:13:11Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Metabolic abnormalities such as diabetes, dyslipidemia, abdominal obesity, metabolic syndrome, and abnormal levels of plasma adipokines have been observed in patients with schizophrenia. This study aimed to investigate the differences and correlations of plasma vaspin levels with metabolic parameters in patients with schizophrenia and to compare with healthy controls. Method: We measured plasma levels of vaspin and metabolic parameters of 100 patients with schizophrenia and 95 healthy controls. Patients with schizophrenia were evaluated with the Positive and Negative Syndrome Scale (PANSS) and The Global Assessment of Functioning. Results: Mean levels of body mass index, waist circumference, triglyceride, and low-density lipoprotein cholesterol of the patients were statistically higher than those of the healthy controls (p = 0.002, p < 0.001, p = 0.03, and p = 0.002, respectively). Plasma levels of vaspin were 0.96 +/- 0.73 ng/ml in patients with schizophrenia and 0.29 +/- 0.15 ng/ml in the healthy controls (p < 0.001). Plasma vaspin levels were statistically higher in patients with schizophrenia than healthy controls both in groups with and without metabolic syndrome and obesity (p < 0.001). Plasma vaspin levels showed a positive correlation with triglyceride in patients with schizophrenia (r = 0.26, p = 0.007). There were positive correlations between vaspin and PANSS scores in schizophrenia patients with obesity (PANSS Positive: r = 0.42, p = 0.01; PANSS Negative: r = 0.42, p = 0.01; PANSS General: r = 0.43, p = 0.01; PANSS Total: r = 0.47, p = 0.006). Conclusions: Our study showed a significant relationship and positive correlation between vaspin and PANSS scores in schizophrenia patients with obesity. Vaspin may play an important role in the metabolic processes of patients with schizophrenia.en_US
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination UnitCanakkale Onsekiz Mart University [TSA-2015-561]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was carried out with the support of Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit with the project number TSA-2015-561.en_US
dc.identifier.citationErtekin, H., Uysal, S., Aydın, M., Ilhan, B., Ertekin, Y. H. (2020). Correlation Between Vaspin and PANSS Scores in Schizophrenia Patients with Obesity. The International Journal of Psychiatry in Medicine, 55(4), 264-280.
dc.identifier.doi10.1177/0091217420905463en_US
dc.identifier.endpage280
dc.identifier.issn0091-2174en_US
dc.identifier.issn1541-3527en_US
dc.identifier.issue4
dc.identifier.pmid32050814en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage264
dc.identifier.urihttps://dx.doi.org/10.1177/0091217420905463
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37639
dc.identifier.volume55
dc.identifier.wosWOS:000513412900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAydın, Memduha.
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectadipokinesen_US
dc.subjectschizophreniaen_US
dc.subjectobesityen_US
dc.subjectmetabolic syndromeen_US
dc.subjectvaspinen_US
dc.subjectinsulin resistanceen_US
dc.titleCorrelation between vaspin and PANSS scores in schizophrenia patients with obesityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Ruh Sağlığı ve Hastalıkları/Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu