Effects of Long-Term Hormone Replacement Therapy on QT and Corrected QT Dispersion During Resting and Peak Exercise Electrocardiography in Post-Menopausal Women

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dc.contributor.authorAltunkeser, Bülent Behlül
dc.contributor.authorÖzdemir, Kurtuluş
dc.contributor.authorİçli, Abdullah
dc.contributor.authorÇelik, Çetin
dc.contributor.authorAkyürek, Cemalettin
dc.contributor.authorGök, Hasan
dc.date.accessioned2020-03-26T16:38:58Z
dc.date.available2020-03-26T16:38:58Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIt is known that the QT interval is longer in women than men. Estrogen is reported to account for the QT interval prolongation in several studies conducted with hormone replacement therapy (HRT) in postmenopausal women. Along with this, there are conflicting data as regards the effects of HRT on QT interval and dispersion. Moreover, there is no evidence about the effect of HRT on exercise QT parameters. We compared QT parameters obtained from Surface electrocardiograms during resting and peak exercise before and after 6 months of HRT consisting of estrogen Plus progesterone in healthy postmenopausal women. Twenty-four healthy postmenopausal women were given 0.625 mg/day conjugated estrogens and 2.5 mg/clay medroxyprogesterone acetate for 6 months. Exercise stress testing using the Bruce protocol was performed before and after HRT. QT maximum, minimum, dispersion and corrected QT maximum, minimum and dispersion were calculated during testing and peak exercise. HRT resulted in a significant increase in estradiol plasma levels from 24+/-10 pg/mL to 117+/-66 pg/mL (P<0.001). There was no significant difference in resting QT parameters after HRT, whereas QT dispersion and corrected QT dispersion were significantly increased during peak exercise (20+/-7 versus 25+/-10 ins; P<0.05, 33+/-12 versus 41+/-16 ms; P<0.05, respectively). Nonetheless, the other exercise QT parameters were unchanged. The resting QT parameters are not affected by long term HRT consisting of estrogen plus progesterone, which leads to an increase in QT dispersion and corrected QT dispersion during peak exercise.en_US
dc.identifier.citationAltunkeser, B. B., Özdemir, K., İçli, A., Çelik, Ç., Akyürek, C., Gök, H., (2002). Effects of Long-Term Hormone Replacement Therapy on QT and Corrected QT Dispersion During Resting and Peak Exercise Electrocardiography in Post-Menopausal Women. Japanese Heart Journal, (43), 1-7. Doi: 10.1536/jhj.43.1
dc.identifier.doi10.1536/jhj.43.1en_US
dc.identifier.endpage7en_US
dc.identifier.issn0021-4868en_US
dc.identifier.pmid12041885en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1536/jhj.43.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17939
dc.identifier.volume43en_US
dc.identifier.wosWOS:000175545800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAltunkeser, Bülent Behlül
dc.institutionauthorÖzdemir, Kurtuluş
dc.institutionauthorİçli, Abdullah
dc.institutionauthorÇelik, Çetin
dc.institutionauthorAkyürek, Cemalettin
dc.institutionauthorGök, Hasan
dc.language.isoenen_US
dc.publisherJapan Heart Journal, Second Dept of Internal Meden_US
dc.relation.ispartofJapanese Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthormone replacement therapyen_US
dc.subjectexercise stress testingen_US
dc.subjectQT dispersionen_US
dc.titleEffects of Long-Term Hormone Replacement Therapy on QT and Corrected QT Dispersion During Resting and Peak Exercise Electrocardiography in Post-Menopausal Womenen_US
dc.typeArticleen_US

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