The relationship between the antioxidant system, oxidative stress and dialysis-related amyloidosis in hemodialysis patients.

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dc.contributor.authorCelik G.
dc.contributor.authorCapraz I.
dc.contributor.authorYontem M.
dc.contributor.authorBilge M.
dc.contributor.authorUnaldi M.
dc.contributor.authorMehmetoglu I.
dc.date.accessioned2020-03-26T18:48:20Z
dc.date.available2020-03-26T18:48:20Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEnd-stage renal disease (ESRD) is associated with several complications that are partly due to excess amounts of reactive oxygen species and/or decreased antioxidant activity. Dialysis-related amyloidosis (DRA) has also been linked to increased oxidative stress. The aim of this study was to investigate the relationships between the antioxidant system, including superoxide dismutase (SOD), malonyldialdehyde (MDA), various biochemical parameters and shoulder amyloidosis, in hemodialysis patients. We studied 107 non-diabetic chronic dialysis patients. The SOD levels correlated with right and left biceps tendon thickness (r = -0.219, P = 0.048 and r = -0.236, P = 0.031, respectively), MDA (r = -0.429, P = 0.000) and albumin levels (r = -0.319, P = 0.001). MDA levels correlated with right and left biceps thickness (r = 0.291, P = 0.006 and r = 0.337, P = 0.001, respectively) and ?2 microglobulin levels (r = 0.455, P = 0.000). We also identified the statistically significant relationships between MDA levels and supraspinatus tendon thickening (greater than 7 mm) and right and left biceps tendon thickness (P = 0.022, P = 0.040 and P = 0.005, respectively). Our data suggest the complex relationship between antioxidants and oxidative stress and further support the roles of oxidative stress and antioxidants in DRA.en_US
dc.identifier.doi10.4103/1319-2442.121272en_US
dc.identifier.endpage1164en_US
dc.identifier.issn1319-2442en_US
dc.identifier.issue6en_US
dc.identifier.pmid24231477en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1157en_US
dc.identifier.urihttps://dx.doi.org/10.4103/1319-2442.121272
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30223
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe relationship between the antioxidant system, oxidative stress and dialysis-related amyloidosis in hemodialysis patients.en_US
dc.typeArticleen_US

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