The influence of aldosterone on the development of left ventricular geometry and hypertrophy in patients with essential hypertension

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dc.contributor.authorSoylu, A
dc.contributor.authorTemizhan, A
dc.contributor.authorDuzenli, MA
dc.contributor.authorSokmen, G
dc.contributor.authorKoylu, O
dc.contributor.authorTelli, HH
dc.date.accessioned2020-03-26T16:55:34Z
dc.date.available2020-03-26T16:55:34Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe identification of risk factors for the initiation of left ventricle hypertrophy (LVH), which is an independent risk factor for cardiovascular mortality and morbidity in hypertensive patients, is very important. The objective of the present Study was to identify the relationship of aldosterone with LVH and different geometrical patterns of left ventricle that develop in patients with essential hypertension. A total of 83 patients with essential hypertension (44 females, mean age, 5 1 8 years, 39 males, mean age, 57 10 years) were included ill this study. Thirty-two had LVH. When evaluated according to the geometrical patterns of LVH, 18 patients had concentric LVH, 14 had eccentric LVH, and 17 had concentric remodeling. Thirty-four patients had normal left ventricle geometry. Two weeks after the cessation of antihypertensive medications, Sodium, potassium, and proteinuria in 24-hour urine samples and plasma aldosterone levels and plasma renin activity were measured. Plasma aldosterone levels of the patients with LVH were found to be significantly higher (9.92 +/- 6.34 ng/dL versus 5.83 +/- 3.5 ng/dL, P < 0.01). The difference between plasma renin activities was not statistically significant. Linear regression analysis revealed that plasma aldosterone level and age were independent parameters increasing left ventricle mass index. The plasma aldosterone levels of patients with concentric hypertrophy of the left ventricle were significantly higher than those of patients with normal geometry and concentric remodeling. There was no significant difference between plasma renin activities. Twenty-four hour Urine protein concentrations of the patients with LVH were found to be significantly higher and sodium to be significantly lower. Plasma aldosterone levels seem to be correlated with LVH especially with concentric hypertrophy of the left ventricle in patients with essential hypertension.en_US
dc.identifier.doi10.1536/jhj.45.807en_US
dc.identifier.endpage821en_US
dc.identifier.issn0021-4868en_US
dc.identifier.issue5en_US
dc.identifier.pmid15557722en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage807en_US
dc.identifier.urihttps://dx.doi.org/10.1536/jhj.45.807
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19246
dc.identifier.volume45en_US
dc.identifier.wosWOS:000226083000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINT HEART JOURNAL ASSOCen_US
dc.relation.ispartofJAPANESE HEART JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectessential hypertensionen_US
dc.subjectleft ventricle hypertrophyen_US
dc.subjectaldosteroneen_US
dc.titleThe influence of aldosterone on the development of left ventricular geometry and hypertrophy in patients with essential hypertensionen_US
dc.typeArticleen_US

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