Diffusion weighted magnetic resonance imaging for the characterization of solitary pulmonary lesions

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dc.contributor.authorÇakır, Cağlayan
dc.contributor.authorGençhellaç, Hakan
dc.contributor.authorTemizöz, Osman
dc.contributor.authorPolat, Ahmet
dc.contributor.authorŞengül, Ersin
dc.contributor.authorDuygulu, Gökhan
dc.date.accessioned2020-03-26T19:01:52Z
dc.date.available2020-03-26T19:01:52Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: We evaluated the differential diagnosis of solitary pulmonary lesions on magnetic resonance imaging. Aims: To investigate the value of diffusion weighted imaging on the differential diagnosis of solitary pulmonary lesions. Study Design: Randomized prospective study. Methods: This prospective study included 48 solitary pulmonary nodules and masses (18 benign, 30 malignant). Single shot echo planar spin echo diffusion weighted imaging (DWI) was performed with two b factors (0 and 1000 s/mm(2)). Apparent diffusion coefficients (ADCs) were calculated. On diffusion weighted (DW) trace images, the signal intensities (SI) of the lesions were visually compared to the SI of the thoracic spinal cord using a 5-point scale: 1: hypointense, 2: moderately hypointense, 3: isointense, 4: moderately hyperintense, 5: significantly hyperintense. For the quantitative evaluation, the lesion to thoracic spinal signal intensity ratios and the ADCs of the lesions were compared between groups. Results: On visual evaluation, taking the density of the spinal cord as a reference, most benign lesions were found to be hypointense, while most of the malignant lesions were evaluated as hyperintense on DWI with a b factor of 1000 s/mm(2). In contrast, on T2 weighted images, it was seen that the distinction of malignant lesions from benign lesions was not statistically significant. The ADCs of the malignant lesions were significantly lower than those of benign lesions (mean ADC was 2.02x10(-3) mm(2)/s for malignant lesions, and 1.195x10(-3)+/- 0.3 mm(2)/s for benign lesions). Setting the cut-off value at 1.5x10(-3), ADC had a sensitivity of 86.7% and a specificity of 88.9% for the differentiation of benign lesions from malignant lesions. Conclusion: DWI may aid in the differential diagnosis of solitary pulmonary lesions. (ClinicalTrials. gov Identifier: NCT02482181)en_US
dc.description.sponsorshipTrakya University HospitalTrakya Universityen_US
dc.description.sponsorshipOur study supported financially by Trakya University Hospital.en_US
dc.identifier.citationÇakır, Ç., Gençhellaç, H., Temizöz, O., Polat, A., Şengül, E., Duygulu, G. (2015). Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions. Balkan Medical Journal, 32(4), 403-409.
dc.identifier.doi10.5152/balkanmedj.2015.15663en_US
dc.identifier.endpage409en_US
dc.identifier.issn2146-3123en_US
dc.identifier.issn2146-3131en_US
dc.identifier.issue4en_US
dc.identifier.pmid26740901en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://dx.doi.org/10.5152/balkanmedj.2015.15663
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32009
dc.identifier.volume32en_US
dc.identifier.wosWOS:000362846400011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTemizöz, Osman
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectb factoren_US
dc.subjectdiffusion weighted magnetic resonance imagingen_US
dc.subjectlung canceren_US
dc.subjectsolitary pulmonary noduleen_US
dc.titleDiffusion weighted magnetic resonance imaging for the characterization of solitary pulmonary lesionsen_US
dc.typeArticleen_US

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