Characteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkey

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dc.contributor.authorYüksel, Hasan
dc.contributor.authorCan, Demet
dc.contributor.authorReisli, İsmail
dc.contributor.authorUzuner, Nevin
dc.contributor.authorOrhan, Fazıl
dc.contributor.authorCevit, Ömer
dc.contributor.authorTahan, Fulya
dc.contributor.authorCanitez, Yakup
dc.contributor.authorKuyucu, Semanur
dc.contributor.authorBingöl Boz, Ayşen
dc.contributor.authorAkçay, Ahmet
dc.contributor.authorYılmaz, Özge
dc.date.accessioned2020-03-26T17:47:23Z
dc.date.available2020-03-26T17:47:23Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Childhood atopic dermatitis (AD) is classically accepted as initial finding of atopic march; however, non-atopic cases do not follow this course. The aim of this study was to determine the characteristics and prognosis of AD in childhood in Turkey. Methods: The study included 531 children with AD that presented to pediatric allergy departments in 11 different regions of Turkey. Age at diagnosis, total serum and inhalant-specific immunoglobulin E (IgE) levels and allergen skin prick test results were recorded retrospectively. Clinical characteristics like additional allergic diseases at presentation or during follow-up were recorded as well as duration of follow-up. Results: Mean age at diagnosis was 37.8 +/- 36.2 months. Mean IgE level was 318.3 +/- 677.8 IU/ml (median 100 IU/ml). Skin prick tests yielded positive results in 47% of children. At presentation, 31.6% of children reported additional allergic disease, while 11.7% developed allergic disease during follow-up. Among all, 46.6% had additional allergic disease at any point. IgE levels were significantly higher in children with additional allergic diseases (p = 0.001). Allergen skin prick test positivity and family history of allergic diseases increased the risk of additional allergic diseases significantly (OR = 3.90, 95% CI = 2.3-6.6 and OR = 1.89, 95% CI = 1.3-2.8, respectively). Conclusions: Allergic sensitization is not present in all cases of AD. Coexistence of additional allergic diseases is not as high as expected but more common in children who have been demonstrated to have atopic sensitization with high IgE levels and allergen skin prick test positivity.en_US
dc.identifier.citationYüksel, H., Can, D., Reisli, İ., Uzuner, N., Orhan, F., Cevit, Ö., Tahan, F., Canitez, Y., Kuyucu, S., Bingöl Boz, A., Akçay, A., Yılmaz, Ö., (2010). Characteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkey. International Archives of Allergy and Immunology, 152(4), 362-367. Doi: 10.1159/000288289
dc.identifier.doi10.1159/000288289en_US
dc.identifier.endpage367en_US
dc.identifier.issn1018-2438en_US
dc.identifier.issn1423-0097en_US
dc.identifier.issue4en_US
dc.identifier.pmid20197678en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000288289
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24685
dc.identifier.volume152en_US
dc.identifier.wosWOS:000279594800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorReisli, İsmail
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAtopic dermatitisen_US
dc.subjectAtopic marchen_US
dc.subjectAllergyen_US
dc.titleCharacteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkeyen_US
dc.typeArticleen_US

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