In Vitro Tyrosinase Inhibitory and Antioxidant Potential of Consolida Orientalis, Onosma Isauricum and Spartium Junceum from Turkey

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dc.authorid0000-0002-8901-6484
dc.authorid0000-0002-5151-2650
dc.authorid0000-0003-3962-8666
dc.authorid0000-0003-4429-6512
dc.authorid0000-0001-8954-5485
dc.authorid0000-0002-5459-7717
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorPicot-Allain, Carene M. N.
dc.contributor.authorÇakmak, Yavuz Selim
dc.contributor.authorUysal, Şengül
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T20:14:41Z
dc.date.available2020-03-26T20:14:41Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractTraditionally used botanical remedies have attracted much interest as pharmacological targets in the management and/or treatment of several diseases. Recently, they have been probed as tyrosinase inhibitors for the management of epidermal hyperpigmentation. This study aims to investigate into the antioxidant and tyrosinase inhibitory potential of methanol, ethyl acetate, and water extracts of three medicinal plants (Consolida orientalis (J. Gay) Schrodinger, Onosma isauricumBoiss. & Heldr. and Spartium junceumL.), fromTurkey. Methanolic extract of O. isauricum and S. junceum showed the highest phenolic (63.08 mgGAE/g extract) and flavonoid contents (45.55 mgRE/g extract). Additionally, O. isauricum methanolic extract exhibited the most powerful antioxidant capacity followed by methanolic extract of S. junceum (86.02 and 62.81 mgAAE/g extract, respectively). S. junceum extracts yielded the higher kojic acid equivalent values (21.42-23.04 mgKAE/g extract), confirming that these extracts were the most potent inhibitors of tyrosinase. S. junceum showed promising activity that warrant further studies and could be considered as a potent candidate for the development of phytoremedies for the management of epidermal hyperpigmentation. To the best of our knowledge, this study can be considered as the first report of on the antioxidant and tyrosinase inhibitory action of C. orientalis, O. isauricum, and S. junceum from Turkey. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.citationZengin, G., Mahomoodally, M. F., Picot-Allain, C. M. N., Cakmak, Y. S., Uysal, S., Aktumsek, A. (2019). In Vitro Tyrosinase Inhibitory and Antioxidant Potential of Consolida orientalis, Onosma isauricum and Spartium junceum from Turkey. South African Journal of Botany, 120, 119-123. doi: https://dx.doi.org/10.1016/j.sajb.2018.01.010
dc.identifier.doi10.1016/j.sajb.2018.01.010en_US
dc.identifier.endpage123en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2018.01.010
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37919
dc.identifier.volume120en_US
dc.identifier.wosWOS:000456314600013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorAktümsek, Abdurrahman
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectTyrosinaseen_US
dc.subjectPhenolicen_US
dc.subjectFlavonoiden_US
dc.subjectHyperpigmentationen_US
dc.subjectEnzyme inhibitorsen_US
dc.subjectBotanical remediesen_US
dc.subjectAntioksidan
dc.subjectTirozinaz
dc.subjectBotanik ilaçlar
dc.subjectFenolik
dc.subjectFlavonoid
dc.subjectHiperpigmentasyon
dc.subjectEnzim inhibitörleri
dc.titleIn Vitro Tyrosinase Inhibitory and Antioxidant Potential of Consolida Orientalis, Onosma Isauricum and Spartium Junceum from Turkeyen_US
dc.typeArticleen_US

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