Treatment of electrical status epilepticus during slow-wave sleep with high-dose corticosteroid

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dc.contributor.authorOkuyaz, C
dc.contributor.authorAydin, KA
dc.contributor.authorGucuyener, K
dc.contributor.authorSerdaroglu, A
dc.date.accessioned2020-03-26T16:58:24Z
dc.date.available2020-03-26T16:58:24Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractA 4-year-old female patient with epilepsy with continuous spike-and-waves during slow-wave sleep not classified as Landau-Klefner syndrome, refractory to antiepileptic drugs including valproate, benzodiazepines, and lamotrigine, was treated successfully with high-dose intravenous methylprednisolone therapy. Valproate, clobazam, and lamotrigine were continued at the same dose during and after high-dose intravenous corticosteroid therapy. During corticosteroid therapy, awake and sleep electroencephalogram was recorded every day. On day 7, a dramatic clinical and electroencephalographic response was observed. After high-dose intravenous methylprednisolone, prednisolone was administered orally (2 mg/kg daily) for 2 months, then gradually withdrawn. After the withdrawal of corticosteroid therapy, the patient maintained the clinical improvement in behavior, and no continuous spike-and-wave electrical status epilepticus during slow-wave sleep occurred on routine monthly sleep electroencephalogram performed for the last 6 months. In the present case, an add-on high-dose intravenous corticosteroid seems to be effective in the treatment of patients with electrical status epilepticus during slow-wave sleep syndrome, especially when antiepileptic drugs fail. (C) 2005 by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pediatrneurol.2004.06.020en_US
dc.identifier.endpage67en_US
dc.identifier.issn0887-8994en_US
dc.identifier.issue1en_US
dc.identifier.pmid15607609en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.pediatrneurol.2004.06.020
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19952
dc.identifier.volume32en_US
dc.identifier.wosWOS:000226406500013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofPEDIATRIC NEUROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleTreatment of electrical status epilepticus during slow-wave sleep with high-dose corticosteroiden_US
dc.typeArticleen_US

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