Phytochemical and biological activities of Silene viridiflora extractives. Development and validation of a HPTLC method for quantification of 20-hydroxyecdysone

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dc.contributor.authorMamadalieva, Nilufar Z.
dc.contributor.authorBoehmdorfer, Stefan
dc.contributor.authorZengin, Gökhan
dc.contributor.authorBacher, Markus
dc.contributor.authorPotthast, Antje
dc.contributor.authorAkramov, Davlat Kh.
dc.contributor.authorJanibekov, Abdulaziz
dc.contributor.authorRosenau, Thomas
dc.date.accessioned2020-03-26T20:19:08Z
dc.date.available2020-03-26T20:19:08Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractSilene viridifiora (Caryophyllaceae) has adaptogen, tonic, actoprotector and immunomodulator properties that are mainly attributed to ecdysteroids. The aim of the present study is to investigate the chemical constituents of essential oil as well as the 20-hydroxyecdysone content in the methanol extract S. viridiflora and its related biological activity. GC-MS analysis showed the essential oil of S. viridifiora to have a complex composition, which was dominated by methyl palmitate (8.05%), 3-hexen-1-ol (7.54%), 3-hexenyl benzoate (3.86%), beta-myrcene (3.80%), 1,1-diethoxy-2-phenylethane (3.65%), hexahydrofarnesyl acetone (3.20%) and 4-terpineol (2.47%). A high performance thin-layer chromatography (HPTLC) method was developed to analyze the methanolic extracts of S. viridifiora and to quantify the main ecdysteroid, 20-hydroxyecdysone. Validation showed that the method was accurate over the entire calibration range and resulted in errors of less than 10% in the 100-815 mu g/ml concentration range. Antioxidant and enzyme inhibitory potentials of methanol extract and individual compounds of S. viridiflora were evaluated. The results could provide a starting point for designing novel phyto-pharmaceuticals.en_US
dc.identifier.citationMamadalieva, N. Z., Böhmdorfer, S., Zengin, G., Bacher, M., Potthast, A., Akramov, D. K., Janibekov, A., Rosenau, T. (2019). Phytochemical and Biological Activities of Silene Viridiflora Extractives. Development and Validation of a HPTLC Method for Quantification of 20-hydroxyecdysone. Industrial Crops and Products, 129, 542-548.
dc.identifier.doi10.1016/j.indcrop.2018.12.041en_US
dc.identifier.endpage548en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage542en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.12.041
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38104
dc.identifier.volume129en_US
dc.identifier.wosWOS:000457504200059en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSilene viridifloraen_US
dc.subjectEssential oilen_US
dc.subjectPlant extractsen_US
dc.subject20-Hydroxyecdysoneen_US
dc.subjectHPTLCen_US
dc.subjectEnzyme inhibitory activityen_US
dc.titlePhytochemical and biological activities of Silene viridiflora extractives. Development and validation of a HPTLC method for quantification of 20-hydroxyecdysoneen_US
dc.typeArticleen_US

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