Phenolic profiling and in vitro bioactivity of Moringa oleifera leaves as affected by different extraction solvents

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dc.contributor.authorRocchetti, Gabriele
dc.contributor.authorPagnossa, Jorge Pamplona
dc.contributor.authorBlasi, Francesca
dc.contributor.authorCossignani, Lina
dc.contributor.authorPiccoli, Roberta Hilsdorf
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMontesano, Domenico
dc.contributor.authorCocconcelli, Pier Sandro
dc.contributor.authorLucini, Luigi
dc.date.accessioned2020-03-26T20:20:25Z
dc.date.available2020-03-26T20:20:25Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractIn this work the (poly)-phenolic profile of Moringa oleifera leaves was comprehensively investigated through untargeted metabolomics, following a homogenizer-assisted extraction (HAE) using three solvent systems, i.e. methanol (HAE-1), methanol-water 50:50 v/v (HAE-2) and ethyl acetate (HAE-3). This approach allowed to putatively annotate 291 compounds, recording mainly flavonoids and phenolic acids. Thereafter, antioxidant capacity, antimicrobial activity and enzyme inhibition were assayed in the different extracts. HAE-1 extract showed the highest total phenolic content (31.84 mg/g), followed by HAE-2 (26.95 mg/g) and HAE-3 (14.71 mg/g). In addition, HAE-1 and HAE-2 extracts exhibited an expressive activity against Bacillus cereus and Listeria innocua. The HAE-2 leaf extract was characterized by the highest DPPH and ARTS values (being 49.55 and 45.26 mgTE/g), while ferric reducing antioxidant power was found to be higher in HAE-1 (58.26 mgTE/g). Finally, the enzyme inhibitory effects of M. oleifera leaf extracts were investigated against five enzymes, namely acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, a-amylase and a-glucosidase. All of the tested extracts exhibited inhibitory effects on AChE and BChE with a higher activity for HAE-3 and HAE-1, whilst HAE-1 showed the higher impact on tyrosinase, glucosidase and amylase activities. Taken together, these findings suggest that M. oleifera leaf extracts are a good source of bioactive polyphenols with a potential use in food and pharma industries.en_US
dc.identifier.citationRocchetti, G., Pagnossa, J. P., Blasi, F., Cossignani, L., Piccoli, R. H., Zengin, G., Montesano, D., Cocconcelli, P. S., Lucini, L. (2020). Phenolic Profiling and in vitro Bioactivity of Moringa oleifera Leaves as Affected by Different Extraction Solvents. Food Research International, 127, 1-8.
dc.identifier.doi10.1016/j.foodres.2019.108712en_US
dc.identifier.issn0963-9969en_US
dc.identifier.issn1873-7145en_US
dc.identifier.pmid31882101en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.foodres.2019.108712
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38582
dc.identifier.volume127en_US
dc.identifier.wosWOS:000509620100036en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofFOOD RESEARCH INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMoringaen_US
dc.subjectFood metabolomicsen_US
dc.subjectEnzymatic activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectAntimicrobial activityen_US
dc.titlePhenolic profiling and in vitro bioactivity of Moringa oleifera leaves as affected by different extraction solventsen_US
dc.typeArticleen_US

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