Synthesis of new calix[4] arene amide derivatives and investigation of their DNA cleavage activity

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dc.contributor.authorOzkan, Seyda Cigdem
dc.contributor.authorYilmaz, Aydan
dc.contributor.authorOzmen, Ismail
dc.date.accessioned2020-03-26T18:58:33Z
dc.date.available2020-03-26T18:58:33Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study comprises the synthesis of new p-tert-butylcalix[4]arene with different amide functional groups and summarises an investigation of their DNA cleavage activities. The structural investigations of the synthesised compounds were examined by FTIR, H-1 NMR, C-13 NMR, elemental analysis and FAB-MS techniques. The interaction between these compounds and pBR322 plasmid DNA has been investigated via agarose gel electrophoresis and, according to the results, compounds 5, 7, 8 and 13 exhibit efficient DNA cleavage activity. In the electrophoresis images of 5, 7 and 8, Form IV which is small DNA fragment was observed in addition to supercoiled Form I, open circular Form II and linear Form III.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University, Konya-TurkeySelcuk University [BAP 2009/10201020]en_US
dc.description.sponsorshipWe thank the Research Foundation of Selcuk University, Konya-Turkey (BAP 2009/10201020) for financial support of this work produced from a part of S.C. Ozkan's MS Thesis.en_US
dc.identifier.doi10.1080/10610278.2013.817578en_US
dc.identifier.endpage31en_US
dc.identifier.issn1061-0278en_US
dc.identifier.issn1029-0478en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://dx.doi.org/10.1080/10610278.2013.817578
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31173
dc.identifier.volume26en_US
dc.identifier.wosWOS:000328599500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofSUPRAMOLECULAR CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcalix[4]areneen_US
dc.subjectDNA cleavageen_US
dc.subjectamideen_US
dc.subjectplasmid DNAen_US
dc.titleSynthesis of new calix[4] arene amide derivatives and investigation of their DNA cleavage activityen_US
dc.typeArticleen_US

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