Multidirectional investigations on different parts of Allium scorodoprasum L. subsp rotundum (L.) Stearn: Phenolic components, in vitro biological, and in silico propensities

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dc.contributor.authorMollica, Adriano
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorPicot-Allain, Carene Marie Nancy
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T19:54:43Z
dc.date.available2020-03-26T19:54:43Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAllium species have been widely used for culinary and medicinal purposes. This study attempts for the first time to investigate into the enzyme inhibitory potential of different plant parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn, also known as wild garlic or leek in Turkey. The antioxidant and enzyme inhibitory potential of the flower, stem, and bulb extracts of A. scorodoprasum were assessed using in vitro bio-assays. The phenolic composition of the different plant parts was also established. The flower extract, having high phenolic content (27.69 mg GAEg extract), showed potent antioxidant activity as a metal chelating agent (22.27 mg EDTAE/g extract), radical scavenger (34.83 and 66.02 mg trolox equivalent (TE)/g extract, for 2,2diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) assays, respectively) and reducing agent (90.53 mg TE/g extract, for the cupric reducing antioxidant capacity assay). Besides, the flower extract was a potent inhibitor of butyrylcholinesterase (3.16 mg galantamine equivalent (GALAE)/g extract) and tyrosinase (55.21 mg kojic acid equivalent/g extract). The flower extract was rich in rosmarinic acid. In silico studies revealed that rosmarinic acid established several hydrogen bonds and pi-pi interactions in the enzymatic cavity of butyrylcholinesterase. On the other hand, the stem extract of A. scorodoprasum showed inhibitory action against acetylcholinesterase (2.17 mg GALAE/g extract) and alpha-amylase (0.55 mmol acarbose equivalent/g extract). Interestingly, we noted that the bulb extract of A. scorodoprasum, inferior in phenolic compounds, showed the least activity. These results suggest that the different plant parts of A. scorodoprasum possessed different biological activities and might be used as a medicinal food plants for specific therapeutic applications.en_US
dc.identifier.doi10.1016/j.foodres.2018.03.064en_US
dc.identifier.endpage649en_US
dc.identifier.issn0963-9969en_US
dc.identifier.issn1873-7145en_US
dc.identifier.pmid29735100en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage641en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.foodres.2018.03.064
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36784
dc.identifier.volume108en_US
dc.identifier.wosWOS:000434005600069en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofFOOD RESEARCH INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlliumen_US
dc.subjectPhenolicsen_US
dc.subjectAntioxidantsen_US
dc.subjectEnzyme inhibitorsen_US
dc.subjectNatural agentsen_US
dc.titleMultidirectional investigations on different parts of Allium scorodoprasum L. subsp rotundum (L.) Stearn: Phenolic components, in vitro biological, and in silico propensitiesen_US
dc.typeArticleen_US

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