Real-time sonography for screening of gallbladder motility in diabetic patients: Relation to autonomic and peripheral neuropathy

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dc.contributor.authorKayaçetin, Ertuğrul
dc.contributor.authorKısakol, Gürcan
dc.contributor.authorKaya, Ahmet
dc.contributor.authorAkpınar, Zehra
dc.date.accessioned2020-03-26T16:46:00Z
dc.date.available2020-03-26T16:46:00Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVES: Diabetes mellitus is known as one of the factors causing the cholesterol gallstone. Gallstone incidence is about 30% in diabetic patients over 20 years of age. Pathophysiology is still not clear. The aim of the present study was to investigate gallbladder (GB) functions in diabetic patients and determine its relationship with peripheral and autonomic neuropathy. DESIGN: Study was performed between October 2001 and may 2002 in fifty-one diabetic patients of similar age and weight. Diabetic patients (n=51) were chosen randomly among diabetic patients, who were being followed in Diabetes Out-patient clinics of Selcuk University, Meram Medical Faculty. Twenty-eight control subjects were chosen from healthy volunteers. We measured fasting and post-prandial gallbladder volumes and ejection fractions by real-time ultrasonography. The patients were divided into three groups; group A (n=18) had no diabetic autonomic and peripheral neuropathy, group B (n=13) had diabetic peripheral neuropathy, group C (n=13) had diabetic autonomic neuropathy. RESULTS: No significant difference in any biochemical parameters between diabetic and control group could be found. Fasting gallbladder volume was significantly higher in the diabetic group (5.31 +/- 0.28 cm(3)) compared to control group (4.19 +/- 0.25 cm(3), p<0.01). But there was no difference within diabetic subgroups. Gallbladder ejection fraction was significantly reduced in diabetic patients in groups B and C (29.7 +/- 1.43%, 28.7 +/- 1.28%) compared to group A (44.8 +/- 2.4%; p < 0.05, p < 0.025 respectively). CONCLUSIONS: Cholesterol crystal formation as a result of increased gallbladder volume and decreased ejection fraction in diabetic patients may result from hypotonicity and stasis and thus this may lead to gallstones.en_US
dc.identifier.endpage76en_US
dc.identifier.issn0172-780Xen_US
dc.identifier.issue01.02.2020en_US
dc.identifier.pmid12743537en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18543
dc.identifier.volume24en_US
dc.identifier.wosWOS:000182800800013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMAGHIRA & MAAS PUBLICATIONSen_US
dc.relation.ispartofNEUROENDOCRINOLOGY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgallbladderen_US
dc.subjectultrasounden_US
dc.subjectdiabetes mellitusen_US
dc.subjectautonomic neuropathyen_US
dc.subjectperipheral neuropathyen_US
dc.titleReal-time sonography for screening of gallbladder motility in diabetic patients: Relation to autonomic and peripheral neuropathyen_US
dc.typeArticleen_US

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