Determination of the cytotoxic effect on human colon cancer and phenolic substance content of the endemic species Sideritis ozturkii Aytaç & Aksoy

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dc.contributor.authorDemirelma, H.
dc.contributor.authorGelinci, E.
dc.date.accessioned2020-03-26T20:13:21Z
dc.date.available2020-03-26T20:13:21Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractSideritis L. species that we based on in this study are annual or perennial flowering plants which are widely used as herbal medicine, and also called mountain tea or shepherd's tea. They are common in the Mediterranean Region, the Balkans, Iberian Peninsula, Greece, Central Asia and Anatolia. They are xerophytic shrub or herbs between 8 and 90 cm. They usually grow on arid cliffs, calcareous slopes, high-altitude mountainous regions (650-1400 m). Full bloom usually occurs in July. It is commonly used in Albania, Greece, Kosova, Bulgaria, Macedonia, Asia, Central Europe and Anatolia as herbal tea and for therapeutic purposes. It is usually used to aid digestion, strengthen the immune system, suppress common cold, allergy, sinusitis and influenza and as therapeutic for pain and mild anxiety. The methanol extracts obtained from the flower and leaf parts of the species Sideritis ozturkii Aytac & Aksoy, which is endemic in Turkey, were applied at different concentrations and for different times on DLD-1 human colorectal cancer cells cultured in RPMI-1640 medium. The cytotoxicity measurements were made through the use of MTT and the cytotoxicity indices were calculated using an Elisa Reader. As a result of the study, it was determined that the flower and leaf extracts obtained from the species Sideritis ozturkii exhibit cytotoxic activity on DLD-1 cells in a dose- and time-dependent manner. It is believed that the extracts obtained from the species Sideritis ozturkii could be beneficial as a natural anti-proliferative agent.en_US
dc.description.sponsorshipSelcuk University BAP (Coordination Office for Scientific Research Projects) [16201095]en_US
dc.description.sponsorshipWe would like to thank Selcuk University BAP (Coordination Office for Scientific Research Projects) for supporting this study with the project no. 16201095.en_US
dc.identifier.citationDemirelma, H., Gelinci, E. (2019). Determination of the Cytotoxic Effect on Human Colon Cancer and Phenolic Substance Content of the Endemic Species Sideritis ozturkii Aytaç & Aksoy. Applied Ecology and Environmental Research, 17(4), 7407-7419.
dc.identifier.doi10.15666/aeer/1704_74077419en_US
dc.identifier.endpage7419en_US
dc.identifier.issn1589-1623en_US
dc.identifier.issn1785-0037en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage7407en_US
dc.identifier.urihttps://dx.doi.org/10.15666/aeer/1704_74077419
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37676
dc.identifier.volume17en_US
dc.identifier.wosWOS:000478066700013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDemirelma, H.
dc.institutionauthorGelinci, E.
dc.language.isoenen_US
dc.publisherCORVINUS UNIV BUDAPESTen_US
dc.relation.ispartofAPPLIED ECOLOGY AND ENVIRONMENTAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSideritisen_US
dc.subjectcytotoxicityen_US
dc.subjectcanceren_US
dc.subjectphenolicen_US
dc.subjectDLD-1en_US
dc.subjectMTTen_US
dc.titleDetermination of the cytotoxic effect on human colon cancer and phenolic substance content of the endemic species Sideritis ozturkii Aytaç & Aksoyen_US
dc.typeArticleen_US

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