Lack of association between serum prolactin and lead exposure among battery workers

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dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorTutkun, Engin
dc.contributor.authorYılmaz, Ömer Hınç
dc.contributor.authorGündüzöz, Meside
dc.contributor.authorBacaksız, Ayşegül
dc.contributor.authorGıynaş, Nilgün
dc.contributor.authorAydın, Emine Gül
dc.date.accessioned2020-03-26T19:06:15Z
dc.date.available2020-03-26T19:06:15Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Serum prolactin (S-PRL) has been reported as a biomarker of early neurotoxic effect related to lead exposure. Raised S-PRL levels are generally considered to provide indirect evidence of reduced dopaminergic tuberoinfundibular (TIDA) activity. Elevated serum prolactin levels were reported due to lead-exposure. Our aim was to determine the relation between serum prolactin levels and lead-exposure. Material: Serum and whole blood samples were collected from 72 non-exposed and 35 lead-exposed male workers. Method: Blood lead was analyzed by Inductively Coupled Plasma - Mass Spectrometer. Serum prolactin levels were analyzed by immunological method. Serum alkaline phosphatase (ALP) and whole blood count were analyzed by using commercial kits. Results: Although serum prolactin levels were higher in control group compared to lead-exposed group (12.7 +/- 7.5 vs. 11.8 +/- 77), this difference was not statistically significant (p = 0.432). Mean corpuscular hemoglobin concentration (MCHC) was significantly higher in control group than lead-exposed group (p < 0.001) and reticulocyte distribution width (RDW) was significantly lower in control group than lead-exposed group (p = 0.031). Serum ALP levels were significantly higher in lead-exposed group than control group (197 51 vs. 133 +/- 65) (p = 0.000). According to Spearman correlation analysis, there was a significantly negative correlation between blood lead levels and MCHC (r = 0.373, p < 0.001). Also, serum ALP levels were positively correlated with blood lead levels (r = 0.436, p < 0.001). The correlation between blood lead levels and RDW was statistically weak (r = 0.225, p = 0.030). Conclusions: Serum prolactin level is not a diagnostic marker for determining the effect of lead-exposure.en_US
dc.identifier.doi10.5414/TEX01367en_US
dc.identifier.endpage85en_US
dc.identifier.issn0946-2104en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://dx.doi.org/10.5414/TEX01367
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32288
dc.identifier.volume32en_US
dc.identifier.wosWOS:000352123900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDUSTRI-VERLAG DR KARL FEISTLEen_US
dc.relation.ispartofTRACE ELEMENTS AND ELECTROLYTESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecttoxicityen_US
dc.subjecthormoneen_US
dc.subjectbiomarkeren_US
dc.subjectindustryen_US
dc.subjecthealthen_US
dc.titleLack of association between serum prolactin and lead exposure among battery workersen_US
dc.typeArticleen_US

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