Glutathione S-Transferase M1 and T1 Polymorphisms in Turkish Patients With Varicocele

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dc.contributor.authorAcar, H.
dc.contributor.authorKılınç, M.
dc.contributor.authorGüven, S.
dc.contributor.authorİnan, Z.
dc.date.accessioned2020-03-26T18:30:39Z
dc.date.available2020-03-26T18:30:39Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSeveral studies have shown that high oxidative stress levels are associated with varicocele. The GST (glutathione S-transferase) family of genes is critical in the protection of cells from oxidative stress because they utilise as substrates a wide variety of products of oxidative stress. The objective of this study was to assess the relationship between genetic polymorphism in GST-M1 and GST-T1 and varicocele using 109 varicocele patients and 123 controls. Varicoceles were clinically graded as Grade 1, Grade 2 and Grade 3. GST-M1 and GST-T1 genes were determined by polymerase chain reaction. Although the GST-M1 null genotype was higher in Grade 3 than in Grade 1, 2 and controls, there were no statistical differences between control group and varicocele groups according to GST-M1 and GST-T1 null genotype. Men with varicocele do not have more GST-M1 and GST-T1 null polymorphisms than men without varicocele. Additional studies are needed to assess the exact mechanism by which the varicocele corresponds to elevated ROS levels.en_US
dc.identifier.citationAcar, H., Kılınç, M., Güven, S., İnan, Z., (2012). Glutathione S-Transferase M1 and T1 Polymorphisms in Turkish Patients With Varicocele. Andrologia, 44(1), 34-37. Doi: 10.1111/j.1439-0272.2010.01103.x
dc.identifier.doi10.1111/j.1439-0272.2010.01103.xen_US
dc.identifier.endpage37en_US
dc.identifier.issn0303-4569en_US
dc.identifier.issue1en_US
dc.identifier.pmid21488930en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1439-0272.2010.01103.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28094
dc.identifier.volume44en_US
dc.identifier.wosWOS:000298788600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, H.
dc.institutionauthorKılınç, M.
dc.institutionauthorGüven, S.
dc.institutionauthorİnan, Z.
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGST-M1en_US
dc.subjectGST-T1en_US
dc.subjectGenotypeen_US
dc.subjectVaricoceleen_US
dc.titleGlutathione S-Transferase M1 and T1 Polymorphisms in Turkish Patients With Varicoceleen_US
dc.typeArticleen_US

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