Osteoprotegerin, rank and rank ligand
| dc.contributor.author | Kurban, Sevil | |
| dc.contributor.author | Mehmetoglu, Idris | |
| dc.date.accessioned | 2020-03-26T17:17:49Z | |
| dc.date.available | 2020-03-26T17:17:49Z | |
| dc.date.issued | 2007 | |
| dc.department | Selçuk Üniversitesi | en_US |
| dc.description.abstract | The discovery of the osteoprotegerin, receptor activator of nuclear factor-kappa B ligand and receptor activator of nuclear factor-kappa B and identification of their role in osteoclastogenesis provided a major advance in bone biology. receptor activator of nuclear factor-kappa B ligand binds to its receptors on the surface of preosteoclasts and stimulates their differentiation into active osteoclasts, leading to bone resorption. Osteoprotegerin is a soluble decoy receptor for the receptor activator of nuclear factor-kappa B ligand thereby inhibiting bone resorption. In addition to providing fundamental insights in bone biology, they may be involved in the immune system, arterial calcification and a number of metabolic bone diseases. In this review, we summarize the roles of receptor activator of nuclear factor-kappa B, receptor activator of nuclear factor-kappa B ligand and osteoprotegerin in bone metabolism, immune system and arterial calcification and discuss their potential in the treatment of these diseases. | en_US |
| dc.identifier.endpage | 184 | en_US |
| dc.identifier.issn | 0250-4685 | en_US |
| dc.identifier.issn | 1303-829X | en_US |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.startpage | 178 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12395/21510 | |
| dc.identifier.volume | 32 | en_US |
| dc.identifier.wos | WOS:000254853100006 | en_US |
| dc.identifier.wosquality | N/A | en_US |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.language.iso | tr | en_US |
| dc.publisher | WALTER DE GRUYTER GMBH | en_US |
| dc.relation.ispartof | TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI | en_US |
| dc.relation.publicationcategory | Diğer | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.selcuk | 20240510_oaig | en_US |
| dc.subject | osteoprotegerin | en_US |
| dc.subject | receptor activator of nuclear factor-kappa B | en_US |
| dc.subject | receptor activator of nuclear factor-kappa B ligand | en_US |
| dc.subject | Bone resorption | en_US |
| dc.subject | Immune system | en_US |
| dc.subject | Arterial calcification | en_US |
| dc.title | Osteoprotegerin, rank and rank ligand | en_US |
| dc.type | Review | en_US |
