The effects of dimethyl sulfoxide on liver damage caused by ischemia-reperfusion

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dc.contributor.authorSahin, M
dc.contributor.authorAvsar, FM
dc.contributor.authorOzel, H
dc.contributor.authorTopaloglu, S
dc.contributor.authorYilmaz, B
dc.contributor.authorPasaoglu, H
dc.contributor.authorAvunduk, MC
dc.date.accessioned2020-03-26T16:55:32Z
dc.date.available2020-03-26T16:55:32Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction. The aim of this study was to investigate the effects of dimethyl sulfoxide on liver damage caused by ischemia-reperfusion after portal vein clamping. Material and methods. Forty New Zealand rabbits were divided into three groups with the portal veins of all the rabbits except the sham group clamped for 30 minutes: group I, sham procedure; group II, control group; and group III, 500 mg/kg DMSO. The drug was administered IM in the left inguinal region 30 minutes before the operation. Blood samples (5 mL) were taken from the animals at 15, 30, and 45 minutes. At the end of the experiment 1 g of liver tissue samples were obtained. Malondialdhyde (MDA), nitric oxide (NO), AST, ALT, and LDH plasma levels were measured in the blood samples. Liver tissue samples stained with hematoxylin eosin were examined under light microscopy for histopathological changes. Finding. The liver enzymes in both clamping groups increased significantly compared with the sham group (P < .01). Enzyme levels of the DMSO group decreased significantly compared to the control clamping group (P < .05). Similar to the enzyme changes, MDA and NO levels increased in the portal vein clamping versus the sham group and decreased in the drug-administered group versus the control clamped group (P < .03). The severity of histopathological changes was less in the DMSO group than in the clamped controls. Conclusion. DMSO decreased the severity of liver damage after portal vein clamping.en_US
dc.identifier.doi10.1016/j.transproceed.2004.09.057en_US
dc.identifier.endpage2592en_US
dc.identifier.issn0041-1345en_US
dc.identifier.issn1873-2623en_US
dc.identifier.issue9en_US
dc.identifier.pmid15621097en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2590en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.transproceed.2004.09.057
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19236
dc.identifier.volume36en_US
dc.identifier.wosWOS:000226142100018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofTRANSPLANTATION PROCEEDINGSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe effects of dimethyl sulfoxide on liver damage caused by ischemia-reperfusionen_US
dc.typeArticleen_US

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