Review of Turkish Patients with Growth-Hormone Insensitivity (Laron Type)

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dc.contributor.authorYordam, Nurşen
dc.contributor.authorKandemir, Nurgün
dc.contributor.authorErkul, İbrahim
dc.contributor.authorKurdoğlu, Selim
dc.contributor.authorHatun, Şükrü
dc.date.accessioned2020-03-26T16:24:33Z
dc.date.available2020-03-26T16:24:33Z
dc.date.issued1995
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractClinical spectrum and endocrine details of thirteen Turkish children (age 0.3-14.2 years; eight females and five males; ten prepubertal, three pubertal) with growth hormone insensitivity are presented. All patients display phenotypical features of severe growth hormone deficiency. The diagnosis based on height standard deviation score (SDS), basal growth hormone (GK), basal insulin-like growth factor I (IGF-I, IGF-I response in an IGF generation test and growth hormone binding protein (GHBP) measurements. The median height SDS was -7.4 (range -3.2 to -10), weight for height index was 100 (range 81-152) and bone age/height age ratio was 2 (range 1.6-3.3). Endocrine investigations showed a median basal GH concentration of 61.4 mU/1 (range 23.5-120mU/l). Basal IGF-I level was below 10 ng/ml in all patients except one. None of the patients showed a significant IGF-I response to injections of GH (0.1 U/kg body weight for 4 days). The median IGFBP-3 level was 0.23 mg/l (range 0.1-0.56 mg/l). The GHBP level was undetectable in all of 10 patients. The high number of patients in our center may be due to the high rate of consanguinity among the Turkish population and the referral facility of our center in the area. These patients may benefit from the new therapy with recombinant human IGF-I.en_US
dc.identifier.citationYordam, N., Kandemir, N., Erkul, İ., Kurdoğlu, S., Hatun, Ş., (1995). Review of Turkish Patients with Growth-Hormone Insensitivity (Laron Type). European Journal of Endocrinology, 133(5), 539-542.
dc.identifier.doi10.1530/eje.0.1330539en_US
dc.identifier.endpage542en_US
dc.identifier.issn0804-4643en_US
dc.identifier.issue5en_US
dc.identifier.pmid7581982en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://dx.doi.org/10.1530/eje.0.1330539
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16296
dc.identifier.volume133en_US
dc.identifier.wosWOS:A1995TD53100006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkul, İbrahim
dc.language.isoenen_US
dc.publisherScandinavian University Pressen_US
dc.relation.ispartofEuropean Journal of Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleReview of Turkish Patients with Growth-Hormone Insensitivity (Laron Type)en_US
dc.typeArticleen_US

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