Arterial Wall Thickening and Stiffening in Children and Adolescents with Type 1 Diabetes

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorKurtoğlu, Selim
dc.contributor.authorPirgon, Özgür
dc.contributor.authorBaykara, Murat
dc.date.accessioned2020-03-26T17:03:05Z
dc.date.available2020-03-26T17:03:05Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: We evaluated structural and functional characteristics of the common carotid artery (CCA), a marker of early carotid atherosclerosis, and investigated their relation to metabolic and anthropometric parameters in children and adolescents with type 1 diabetes. Materials and methods: Non-invasive ultrasonographic measurements were made in 45 type I diabetic patients and 33 controls. Age, sex, and body mass index were matched between patients and controls. We investigated intima-media thickness (IMT), compliance, distensibility, diastolic wall stress (DWS) and incremental elastic modulus (IEM) of the CCA. Metabolic and anthropometric parameters such as serum lipids, plasma glycated haemoglobin, body mass index, waist-hip ratio and blood pressure were assessed. Results: The diabetic patients had significantly higher CCA-IMT than the controls (0.48 +/- 0.06 mm versus 0.33 +/- 0.07 mm; p < 0.001). The diabetic children had significantly higher values than the controls for DWS (1.18 +/- 0.29 mmHg x 102 versus 0.81 +/- 0.25 mmHg x 10(2); p < 0.001) and for IEM (1.26 +/- 0.57 mmHg x 10(3) versus 0.77 +/- 0.28 mmHg x 10(3); P < 0.001). The difference was not significant between patients and controls for arterial compliance and for distensibility (p > 0.05). In a multivariate regression model for all subjects, diabetic state was the best predictor of IMT (p < 0.001), DWS (p < 0.001) and IEM (p = 0.001). Conclusion: Our results suggested that children and adolescent patients with type I diabetes are associated with early impairment of CCA structure and function and that diabetic state may be the main risk factor for CCA wall stiffening and thickening, which are of considerable concern as possible early events in the genesis of atheroma.en_US
dc.identifier.citationAtabek, M. E., Kurtoğlu, S., Pirgon, Ö., Baykara, M., (2006). Arterial Wall Thickening and Stiffening in Children and Adolescents with Type 1 Diabetes. Diabetes Research and Clinical Practice, (74), 33-40. Doi: 10.1016/j.diabres.2006.03.004
dc.identifier.doi10.1016/j.diabres.2006.03.004en_US
dc.identifier.endpage40en_US
dc.identifier.issn0168-8227en_US
dc.identifier.pmid16621108en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.diabres.2006.03.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20341
dc.identifier.volume74en_US
dc.identifier.wosWOS:000240801400006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAtabek, Mehmet Emre
dc.institutionauthorPirgon, Özgür
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofDiabetes Research and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectType 1 diabetesen_US
dc.subjectEarly atherosclerosisen_US
dc.subjectCommon carotid arteryen_US
dc.titleArterial Wall Thickening and Stiffening in Children and Adolescents with Type 1 Diabetesen_US
dc.typeArticleen_US

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