Electrochemical Studies of Olmesartan Medoxomil and its Detection in Pharmaceutical Dosage Forms and Biological Fluids by Cathodic Adsorptive Stripping Voltammetric Method

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dc.contributor.authorÖztürk, Funda
dc.contributor.authorKüçükkolbaşı, Semahat
dc.contributor.authorKaçar, Ceren
dc.contributor.authorKılıç, Esma
dc.date.accessioned2020-03-26T18:50:27Z
dc.date.available2020-03-26T18:50:27Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe electrochemical properties of olmesartan (OLME) were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at hanging mercury drop electrode (HMDE). All studies were based on the irreversible and adsorption-controlled electrochemical reduction signal of OLME at about -1.2 and -1.5 V vs. Ag/AgCl at pH 5.0 in Britton-Robinson (BR) buffer. This adsorptive character of the molecule was used to develop a novel, fully validated, rapid, selective and simple differential pulse cathodic adsorptive stripping voltammeric (DPCAdSV) method for the direct determination of OLME in pharmaceutical dosage form and human urine without time-consuming steps prior to drug assay. Peak current of electrochemical reduction of OLME was found to vary linearly with the concentration in the range from 4.7 x 10(-8) mol L-1 (0.0262 mu g mL(-1)) to 8.3 x 10(-6) mol L-1 (4.636 mu g mL(-1)). In this method, limit of quantification (LOQ) was found to be 5.1 x 10(-7) mol L-1 (0.284 mu g mL(-1)). The method was applied to determine the content of OLME in commercial pharmaceutical preparation and spiked human urine. It was found to be highly accurate and precise, having a relative standard deviation of less than 10% for all applications.en_US
dc.identifier.doi10.5935/0103-5053.20140063en_US
dc.identifier.endpage927en_US
dc.identifier.issn0103-5053en_US
dc.identifier.issn1678-4790en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage920en_US
dc.identifier.urihttps://dx.doi.org/10.5935/0103-5053.20140063
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30814
dc.identifier.volume25en_US
dc.identifier.wosWOS:000335817400016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSOC BRASILEIRA QUIMICAen_US
dc.relation.ispartofJOURNAL OF THE BRAZILIAN CHEMICAL SOCIETYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectolmesartanen_US
dc.subjectdifferential pulse cathodic adsorptive stripping voltammetryen_US
dc.subjectpharmaceutical dosage formen_US
dc.titleElectrochemical Studies of Olmesartan Medoxomil and its Detection in Pharmaceutical Dosage Forms and Biological Fluids by Cathodic Adsorptive Stripping Voltammetric Methoden_US
dc.typeArticleen_US

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