Tigecycline Therapy in an Infant for Ventriculoperitoneal Shunt Meningitis

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dc.contributor.authorEmiroğlu, Melike
dc.contributor.authorAlkan, Gülsüm
dc.contributor.authorDağı, Hatice Türk
dc.date.accessioned2020-03-26T19:43:14Z
dc.date.available2020-03-26T19:43:14Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractShunt infections are seen in 3% to 20% of patients who have cerebrospinal fluid (CSF) shunts. Although the staphylococcal species are the most common cause of shunt-related infections, Gram-negative bacteria are increasingly reported with higher mortality rates. Tigecycline, a glycylcycline, is not approved for children. But in the era of nosocomial infections due to multidrug-resistant pathogens, it can be the life-saving option. We report an infant with ventriculoperitoneal shunt-related meningitis treated with a tigecycline combination regimen. A 5-month-old boy who had a ventriculoperitoneal shunt was admitted with meningitis. Extended spectrum beta-lactamase-producing Klebsiella pneumoniae grew in the CSF. At the end of the fourth week of intravenous meropenem plus gentamicin therapy, carbapenem-resistant K pneumoniae grew in the CSF (mean inhibitory concentration value for meropenem >4 mu g/mL, by E-test). The infected shunt was removed, and an external ventricular drainage catheter was inserted. With permission, intravenous tigecycline (1.2 mg/kg per dose twice a day) and intrathecal amikacin were added to the meropenem. Intrathecal amikacin could be given for only 7 days. On the sixth day of tigecycline treatment, the CSF was sterilized. Antibiotic therapy was given and consisted of a total of 60 days of meropenem and 20 days of tigecycline therapy. Because no available efficacy and safety data from randomized-controlled studies exist, tigecycline must be used only as salvage therapy, in combination with other drugs, for critically ill children who have no alternative treatment options.en_US
dc.identifier.doi10.1542/peds.2016-0963en_US
dc.identifier.issn0031-4005en_US
dc.identifier.issn1098-4275en_US
dc.identifier.issue1en_US
dc.identifier.pmid27974589en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1542/peds.2016-0963
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35632
dc.identifier.volume139en_US
dc.identifier.wosWOS:000392122000012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER ACAD PEDIATRICSen_US
dc.relation.ispartofPEDIATRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleTigecycline Therapy in an Infant for Ventriculoperitoneal Shunt Meningitisen_US
dc.typeArticleen_US

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