Role of the Endothelium on the Response to Adrenoceptor Agonists of Rabbit Aorta During Cooling

Basit Öğe Kaydı
dc.contributor.authorAtalık, Esra K.
dc.contributor.authorŞahin, Ayşe S.
dc.contributor.authorKılıç, Mehmet
dc.contributor.authorDoğan, Necdet
dc.date.accessioned2020-03-26T16:36:19Z
dc.date.available2020-03-26T16:36:19Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe role of the endothelium in the effects of cooling on the response to alpha(1)- and alpha(2)-adrenoceptor agonists of rabbit aorta was studied. The contractions induced by clonidine (10(-9)-3 x 10(-4) M) and xylazine(10(-7)-10(-3) M) but not phenylephrine (10(-9)-3 x 10(-4) M) and methoxamine (10(-9)-3 x 10(-4) M) were enhanced in endothelium-denuded or N-G-nitro-L arginine methyl esther (L-NAME) (10(-5) M) pretreated rabbit aorta. The senstivity, but not the maximal response, of both alpha(1)- and alpha(2)-adrenoceptor agonists was significantly lower at 28 degrees C (cooling) than at 37 degrees C. Endothelium removal did not affect the action of cooling. These results were taken as evidence for the specificity of alpha(2)-adrenoceptor agonists on the production and release of nitric oxide from vascular endothelium. The results suggest that the endothelium seems to have no role in the cooling-induced responses of both alpha(1)- and alpha(2)-adrenoceptors. (C) 2000 Editions scientifiques et medicales Elsevier SAS.en_US
dc.identifier.citationAtalık, E. K., Şahin, A. S., Kılıç, M., Doğan, N., (2000). Role of the Endothelium on the Response to Adrenoceptor Agonists of Rabbit Aorta During Cooling. Fundamental & Clinical Pharmacology, 14(1), 25-30.
dc.identifier.endpage30en_US
dc.identifier.issn0767-3981en_US
dc.identifier.issue1en_US
dc.identifier.pmid10681071en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17246
dc.identifier.volume14en_US
dc.identifier.wosWOS:000085090000004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAtalık, Esra K.
dc.institutionauthorŞahin, Ayşe S.
dc.institutionauthorKılıç, Mehmet
dc.institutionauthorDoğan, Necdet
dc.language.isoenen_US
dc.publisherEditions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaorta (rabbit)en_US
dc.subjecttemperatureen_US
dc.subjectnitric oxideen_US
dc.subjectalpha(1)-adrenoceptorsen_US
dc.subjectalpha(2)-adrenoceptorsen_US
dc.titleRole of the Endothelium on the Response to Adrenoceptor Agonists of Rabbit Aorta During Coolingen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
7246.pdf
Boyut:
470.9 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıbbi Farmakoloji/Makale Koleksiyonu