Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A comprehensive evaluation

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorAtasagun, Bayram
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorSaleem, Hammad
dc.contributor.authorMollica, Adriano
dc.contributor.authorBahadori, Mir Babak
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:19:08Z
dc.date.available2020-03-26T20:19:08Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe genus Salvia and Thymus have gained much popularity as an alternative therapy in Turkish folk medicine for abdominal pain, cold, nausea, among others. Nonetheless, some species are yet to be further explored for their bioactivities. We investigated the biological activities of 3 extracts (dichloromethane, methanol, and water (decoction)) of Salvia modesta Boiss. and Thymus argaeus (Fisch. & C.A.Mey.) Boiss. & Balansa. based on antioxidant and enzyme inhibition along with the determination of polyphenolic content. Antioxidant potential was assessed using six assays namely: 2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid), cupric ion reducing antioxidant capacity, ferric reducing antioxidant power, phosphomolybdenum, and metal chelating. Moreover, enzyme inhibition activities of the extracts were studied against acetylcholinesterase, butyrylcholinesterase, tyrosinase, a-amylase, and a-glucosidase. Results revealed that the decoction of both plants was the strongest antioxidants. The methanol extracts displayed the highest tyrosinase inhibition while the dichloromethane extracts of both plants were the most effective butyrylcholinesterase and a-glucosidase inhibitors. In addition, the total phenolic and total flavonoid content was highest in the decoction and methanolic extract of Thymus argaeus, respectively. The most abundant phenolic compound was rosmarinic acid (6574 mu g/g and 5390 mu g/g in T. argaeus and S. modesta methanolic extracts, respectively). PASS prediction analysis revealed that chlorogenic acid showed the highest Pa value for antioxidant activity (0.809) including the mechanism of free radical scavenging (0.856), while rosmarinic acid showed the highest Pa value (0.798) for antidiabetic activity. To conclude, both Salvia modesta and Thymus argaeus can be regarded as new sources of antioxidants and enzyme inhibitors to manage oxidative stress and their complications.en_US
dc.identifier.citationZengin, G., Atasagun, B., Aumeeruddy, M. Z., Saleem, H., Mollica, A., Bahadori, M. B., Mahomoodally, M. F. (2019). Phenolic Profiling and in vitro Biological Properties of Two Lamiaceae Species (Salvia modesta and Thymus argaeus): A Comprehensive Evaluation. Industrial Crops and Products, 128, 308-314.
dc.identifier.doi10.1016/j.indcrop.2018.11.027en_US
dc.identifier.endpage314en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage308en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.11.027
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38094
dc.identifier.volume128en_US
dc.identifier.wosWOS:000456899400036en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSalvia modestaen_US
dc.subjectThymus argaeusen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPhytochemicalen_US
dc.titlePhenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A comprehensive evaluationen_US
dc.typeArticleen_US

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