Biological, chemical and in silico fingerprints of Dianthus calocephalus Boiss.: A novel source for rutin

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dc.contributor.authorUysal, Şengül
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorPicot-Allain, Carene M. N.
dc.contributor.authorÜnüvar, Hamiyet
dc.contributor.authorMollica, Adriano
dc.contributor.authorGeorgiev, Milen I.
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T19:52:59Z
dc.date.available2020-03-26T19:52:59Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractExtracts (methanol, ethyl acetate, and water) from Dianthus calocephalus Boiss. prepared by different extraction techniques (maceration, Soxhlet, and ultrasonication) were studied for possible inhibitory action against key enzymes (alpha-amylase, alpha-glucosidase, acetyl cholinesterase, butyryl cholinesterase, and tyrosinase). Antioxidant potential was established using a battery of assays and phenolic compounds profiled by RP-HPLC. Binding pose of tyrosinase with rutin was studied by means of molecular docking. Methanol extracts showed the highest phenolic (39.35-40.25 mgGAE/g) content and rich in rutin (61.38-72.07 mg/g extract). Ethyl acetate extracts of D. calocephalus were potent inhibitors of acetyl (1.45-1.48 mgGALAE/g) and butyryl (2.44-2.74 mgGALAE/g) cholinesterases. Docking studies showed that rutin interacts with the side chains of the key amino acid residues and to the copper atom found at the active site of tyrosinase. Methanol extracts showed highest antioxidant capacity. D. calocephalus showed interesting biological properties that could be further studied to manage diabetes, neurodegenerative diseases, Alzheimer's disease, and hyperpigmentation.en_US
dc.identifier.doi10.1016/j.fct.2018.01.049en_US
dc.identifier.endpage186en_US
dc.identifier.issn0278-6915en_US
dc.identifier.issn1873-6351en_US
dc.identifier.pmid29407471en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage179en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2018.01.049
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36366
dc.identifier.volume113en_US
dc.identifier.wosWOS:000428498100020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectalpha-amylaseen_US
dc.subjectCholinesterasesen_US
dc.subjectTyrosinaseen_US
dc.subjectPhenolicsen_US
dc.subjectMolecular docking and dynamicsen_US
dc.subjectNatural agentsen_US
dc.titleBiological, chemical and in silico fingerprints of Dianthus calocephalus Boiss.: A novel source for rutinen_US
dc.typeArticleen_US

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