The relationship between erythrocyte zinc levels and isotretinoin use in acne vulgaris patients

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dc.contributor.authorBilgiç, Özlem
dc.contributor.authorAltınyazar, Hilmi Cevdet
dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorÜnlü, Ali
dc.date.accessioned2020-03-26T19:07:38Z
dc.date.available2020-03-26T19:07:38Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Prior studies have demonstrated lower serum zinc levels in acne vulgaris (AV) patients compared with controls. However, no study has investigated the relationship between AV and erythrocyte zinc levels, which is a superior indicator of body zinc levels. Additionally, the potential influence of isotretinoin use on body zinc status remains to be evaluated. In this study, we aimed to determine erythrocyte zinc levels and their relationship with isotretinoin use in AV patients. Methods: The enrolled study participants included 106 (68% female) isotretinoin-treated AV patients, 89 (65% female) untreated AV patients and 100 (59% female) healthy volunteers between 18 and 30 years of age. The acne severity of the AV patients who did not receive treatment was assessed using the classification system of the International Consensus Conference on Acne. Erythrocyte zinc levels were analysed by atomic absorption spectroscopy. Results: No significant differences were observed among the three groups with respect to erythrocyte zinc levels. In addition, erythrocyte zinc levels did not vary according to the severity of AV, nor according to the duration of isotretinoin use. Conclusion: This study suggests that no relationships exist among zinc status, AV and isotretinoin use. However, given the relationship between vitamin A and zinc, and the fact that previous studies have indicated low serum zinc levels in AV patients, prospective studies are required to corroborate our data.en_US
dc.identifier.doi10.3109/15569527.2014.979426en_US
dc.identifier.endpage306en_US
dc.identifier.issn1556-9527en_US
dc.identifier.issn1556-9535en_US
dc.identifier.issue4en_US
dc.identifier.pmid25373485en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://dx.doi.org/10.3109/15569527.2014.979426
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32679
dc.identifier.volume34en_US
dc.identifier.wosWOS:000371395000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofCUTANEOUS AND OCULAR TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcne vulgarisen_US
dc.subjecterythrocyte zinc levelen_US
dc.subjectisotretinoinen_US
dc.subjectvitamin Aen_US
dc.subjectzincen_US
dc.titleThe relationship between erythrocyte zinc levels and isotretinoin use in acne vulgaris patientsen_US
dc.typeArticleen_US

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