Effects of Ginseng and Echinacea on Cytokine mRNA Expression in Rats

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dc.contributor.authorUluisik, Deniz
dc.contributor.authorKeskin, Ercan
dc.date.accessioned2020-03-26T18:25:15Z
dc.date.available2020-03-26T18:25:15Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the study was to determine the effect of ginseng and echinacea on the mRNA expression of IL-10, TNF-alpha, and TGF-beta 1 in healthy rats. Six-week-old male Fischer 344 rats (n = 48) were used. The animals were divided into three equal groups, as follows: control (C); ginseng (G); echinacea (E). While the C group was fed a standard rat diet (Purina) ad libitum for a period of 40 days, the G and E groups animals received the same diet containing 0.5 g/kg of Panax ginseng root powder and 0.75 g/kg of Echinacea purpurea root powder, respectively. Blood samples were obtained from 8 rats in each group after 20 and 40 days of treatment, and the mRNA expression of IL-10, TNF-alpha, and TGF-beta 1 was determined. After 20 days of treatment, the expression of IL-10mRNA in the G group was different from the C group (P < 0.05); however, after 40 days of treatment, there was no difference between the groups. There was no difference after 20 and 40 days of treatment between the groups with respect to the expression of TGF-beta 1 mRNA. After 20 days of treatment, the expression of TNF-alpha mRNA in the E group was higher (P < 0.05) than the C group. After 40 days of treatment, the expression of TNF-alpha mRNA was similar in all of the groups. Based on the current study, the increase in expression of IL-10 mRNA in the G group and the increase in expression of TNF-alpha mRNA in the E group support the use of these plants for purposes of modulating the immune system. However, a more detailed study regarding the effects of ginseng and echinacea on these cytokines and other cytokines is needed.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Selcuk UniversitySelcuk University [06102036]en_US
dc.description.sponsorshipThis study was supported by The Scientific Research Projects Coordination Unit of Selcuk University (Project no. 06102036).en_US
dc.identifier.doi10.1100/2012/942025en_US
dc.identifier.issn1537-744Xen_US
dc.identifier.pmid22666172en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1100/2012/942025
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27981
dc.identifier.wosWOS:000307073000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofSCIENTIFIC WORLD JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffects of Ginseng and Echinacea on Cytokine mRNA Expression in Ratsen_US
dc.typeArticleen_US

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