Evaluation of Antioxidant, Enzyme Inhibition, and Cytotoxic Activity of Three Anthraquinones (Alizarin, Purpurin, and Quinizarin)

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dc.authorid0000-0002-8901-6484
dc.authorid0000-0002-8537-3978
dc.contributor.authorZengin, Gökhan
dc.contributor.authorDeğirmenci, Sena
dc.contributor.authorAlpsoy, Lokman
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T19:24:03Z
dc.date.available2020-03-26T19:24:03Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü
dc.description.abstractObjective: The aim of this work was to investigate the cytotoxic, antioxidative, and enzyme inhibition effects of alizarin, quinizarin, and purpurin, which are anthraquinones (AQ). Methods: Cytotoxic effects were evaluated with cell inhibition rate by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide assay. Different chemical assays, including free radical scavenging activity (1,1-diphenyl-2-picrylhydrazyl and 2,2-azino-bis(3-ethylbenzothiazloine-6-sulfonic acid)), phosphomolybdenum and reducing power (ferric reducing antioxidant power and cupric ion reducing activity), were used to evaluate the antioxidant properties. Moreover, enzyme inhibitory activities were analyzed against acetylcholinesterase, butrylcholinesterase, tyrosinase, -amylase, and -glucosidase. Results: These components have antioxidant and enzyme inhibition activity. Especially, purpurin showed the strongest antioxidant and good enzyme inhibitory effects. According to our cytotoxicity results, alizarin, purpurin, and quinizarin induced dose- and time-dependent cell proliferation. Furthermore, when we applied AQs with mitomycin C (MC) on L929 cell line, we demonstrated that cell proliferation in MC-AQ groups compared with MC group was increased. The most effective component was alizarin at 100 mu M concentration. These AQs showed positive effects on L929 cell lines with high half-maximal inhibitory concentration values. Conclusion: Our results demonstrate that AQs may be used as antioxidative compounds in food and medicinal applications.en_US
dc.identifier.citationZengin, G., Değirmenci, N. S., Alpsoy, L., Aktümsek, A. (2016). Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin). Human and Experimental Toxicology, 35, (5), 544-553. doi: https://dx.doi.org/10.1177/0960327115595687
dc.identifier.doi10.1177/0960327115595687en_US
dc.identifier.endpage553en_US
dc.identifier.issn0960-3271en_US
dc.identifier.issn1477-0903en_US
dc.identifier.issue5en_US
dc.identifier.pmid26178874en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage544en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0960327115595687
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33564
dc.identifier.volume35en_US
dc.identifier.wosWOS:000375574200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorAktümsek, Abdurrahman
dc.language.isoenen_US
dc.publisherSAGE Publicationsen_US
dc.relation.ispartofHuman and Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlizarinen_US
dc.subjectPurpurinen_US
dc.subjectQuinizarinen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectCytotoxic effecten_US
dc.titleEvaluation of Antioxidant, Enzyme Inhibition, and Cytotoxic Activity of Three Anthraquinones (Alizarin, Purpurin, and Quinizarin)en_US
dc.typeArticleen_US

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