Pharmacokinetics of levamisole in the red-eared slider turtles (Trachemys scripta elegans)

Basit Öğe Kaydı
dc.contributor.authorCorum, Orhan
dc.contributor.authorDurna Corum, Duygu
dc.contributor.authorAtik, Orkun
dc.contributor.authorAltan, Feray
dc.contributor.authorEr, Ayse
dc.contributor.authorUney, Kamil
dc.date.accessioned2020-03-26T20:19:07Z
dc.date.available2020-03-26T20:19:07Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe pharmacokinetics and bioavailability of levamisole were determined in red-eared slider turtles after single intravenous (IV), intramuscular (IM), and subcutaneous (SC) administration. Nine turtles received levamisole (10 mg/kg) by each route in a three-way crossover design with a washout period of 30 days. Blood samples were collected at time 0 (pretreatment), and at 0.25, 0.5, 1, 1.5, 3, 6, 9, 12, 18, 24, 36, and 48 hr after drug administration. Plasma levamisole concentrations were determined by a high-performance liquid chromatography assay. Data were analyzed by noncompartmental methods. The mean elimination half-life was 5.00, 7.88, and 9.43 hr for IV, IM, and SC routes, respectively. The total clearance and volume of distribution at steady state for the IV route were 0.14 L hr(-1) kg(-1) and 0.81 L/kg, respectively. For the IM and SC routes, the peak plasma concentration was 9.63 and 10.51 mu g/ml, respectively, with 0.5 hr of T-max. The bioavailability was 93.03 and 115.25% for the IM and SC routes, respectively. The IM and SC route of levamisole, which showed the high bioavailability and long t(1/2z), can be recommended as an effective way for treating nematodes in turtles.en_US
dc.identifier.citationCorum, O., Durna Corum, D., Atik, O., Altan, F., Er, A., Uney, K. (2019). Pharmacokinetics Of Levamisole İn The Red‐Eared Slider Turtles (Trachemys Scripta Elegans). Journal Of Veterinary Pharmacology And Therapeutics, 42,(6), 654-659.
dc.identifier.doi10.1111/jvp.12763en_US
dc.identifier.endpage659en_US
dc.identifier.issn0140-7783en_US
dc.identifier.issn1365-2885en_US
dc.identifier.issue6en_US
dc.identifier.pmid30933367en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage654en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jvp.12763
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38084
dc.identifier.volume42en_US
dc.identifier.wosWOS:000501034000011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUney, Kamil
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.selcuk20240510_oaigen_US
dc.subjectbioavailabilityen_US
dc.subjectlevamisoleen_US
dc.subjectpharmacokineticsen_US
dc.subjectred-eared slider turtlesen_US
dc.titlePharmacokinetics of levamisole in the red-eared slider turtles (Trachemys scripta elegans)en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
KAMİL UNEY1.pdf
Boyut:
434.68 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Klinik Öncesi Bilimler/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu