Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp detonsa

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dc.contributor.authorFormisano, Carmen
dc.contributor.authorSirignano, Carmina
dc.contributor.authorRigano, Daniela
dc.contributor.authorChianese, Giuseppina
dc.contributor.authorZengin, Gökhan
dc.contributor.authorSeo, Ean-Jeong
dc.contributor.authorEfferth, Thomas
dc.date.accessioned2020-03-26T19:33:56Z
dc.date.available2020-03-26T19:33:56Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe apolar organic extract obtained from aerial parts of Centaurea drabifolia Sibth. & Sm. subsp. detonsa (Bornm.) Wagenitz, growing wild in Turkey, was investigated for the first time for its secondary metabolite composition. Seven sesquiterpene lactones belonging to the guaiane class (1-7), including the new compound 4, along with a fatty acid lactone derivative (8), were isolated. The structures of these compounds were established by spectroscopic analysis, including 2D NMR spectroscopic techniques, with the stereostructure of the new guaiane 4 determined with the help of MTPA derivatization. Cytotoxic activities of compounds 1-7 were evaluated against two cancer cell lines, namely acute lymphoblastic leukemia (CCRF-CEM) and its multidrug-resistant subline CEM/ADR5000. Results showed that aguerin B (1) and cynaropicrin (2) showed a potent activity on both cell lines revealing interesting details about the structure-activity relationships in the class of acylated guaiane sesquiterpenes.en_US
dc.identifier.doi10.1016/j.fitote.2017.05.016en_US
dc.identifier.endpage102en_US
dc.identifier.issn0367-326Xen_US
dc.identifier.issn1873-6971en_US
dc.identifier.pmid28579551en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fitote.2017.05.016
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34811
dc.identifier.volume120en_US
dc.identifier.wosWOS:000407404000014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofFITOTERAPIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCentaurea drabifoliaen_US
dc.subjectSesquiterpene lactonesen_US
dc.subjectCynaropicrinen_US
dc.subjectAntileukemic activityen_US
dc.subjectMultidrug-resistant cell linesen_US
dc.titleAntiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp detonsaen_US
dc.typeArticleen_US

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