A Comparison of the Effects of Adcon-L, Mitomycin C and Sodium Hyaluronate in Experimental Epidural Fibrosis in Rabbits

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dc.contributor.authorKaya, Bulent
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorUstun, Mehmet Erkan
dc.date.accessioned2020-03-26T18:08:09Z
dc.date.available2020-03-26T18:08:09Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Epidural fibrosis and leptomeningeal adhesion formation are among the common causes of failed back surgery syndrome. Various materials have been used to prevent the compressive effect of postoperative epidural fibrosis on neural structures. The effects of Adcon L, Mitomycin C and sodium hyaluronate on epidural fibrosis compared in this experimental study. Methods: 28 rabbits divided into 4 different groups. L5 total laminectomy performed under ketamine and xyzlazine anasthesia. Group1 settled as control group and had no medications after laminectomy. Adcon L in group 2, Mitomycin C in group3 and sodium hyaluronate in group 4 were applied to laminectomy area. All groups sacrified 6 weeks after laminectomy. Histologic slices were invastigated under light microscobe according to their histopathological features and the groups were compared. Result: Grade 3 fibrosis determinated in group1. Statistically significant differences between group1 and all other groups were obtained (p < 0.05) No statistically significant differences was determinated between group 2, 3 and 4 respectively. Conclusions: All medications we use decreased postoperative epidural fibrosis in this study. But further studies are needed for routine application of these medications.en_US
dc.identifier.endpage242en_US
dc.identifier.issn1302-1664en_US
dc.identifier.issue2en_US
dc.identifier.startpage236en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26042
dc.identifier.volume28en_US
dc.identifier.wosWOS:000290234700010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherJOURNAL NEUROLOGICAL SCIENCESen_US
dc.relation.ispartofJOURNAL OF NEUROLOGICAL SCIENCES-TURKISHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEpidural fibrosisen_US
dc.subjectAdcon Len_US
dc.subjectMitomycin Cen_US
dc.subjectsodium hyaluronateen_US
dc.subjectFailed back surgery syndromeen_US
dc.titleA Comparison of the Effects of Adcon-L, Mitomycin C and Sodium Hyaluronate in Experimental Epidural Fibrosis in Rabbitsen_US
dc.typeArticleen_US

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