Protective effects of methotrexate and tenoxicam in peridural fibrosis in rat laminectomy model

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dc.contributor.authorKasımcan, Mustafa Ömür
dc.contributor.authorKaptan, Hülagü
dc.contributor.authorAktaş, Savaş
dc.contributor.authorBakar, Bülent
dc.contributor.authorKarabağlı, Hakan
dc.date.accessioned2020-03-26T19:08:06Z
dc.date.available2020-03-26T19:08:06Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Peridural fibrosis after laminectomy is an important surgical problem. Tenoxicam is a nonsteroidal antiinflammatory drug and an oxicam derivative acting by inhibiting the formation of prostaglandin and eicosanoids. Low dose methotrexate which has been used as an antiinflammatory agent rhomatoid arthritis inhibits the synthesis of potentially toxic compounds those accumulate in inflamed tissues. The aim of this study was to evaluate and compare the efficacy of these two independent pharmacological agents in the inhibition of peridural fibrosis. Methods: L3-4-5 bilateral laminectomy with sparing the dura mater integrity was perfomed to 30 male Wistar albino rats. Except the SHAM group, low dose methotraxate (0.2 mg/kg) or tenoxicam (0.5 mg/kg) was administered on the dura mater before the surgical closure. After 42 days, all rats were euthanized and their spinal columns performed laminectomy were removed for the histopathological evaluation. Results: The peridural fibrosis grades of the groups administered low dose methotrexate or tenoxicam were lower than SHAM group grades. They have lower fibroblast counts than SHAM group numerically, although there was no statistically significant difference among groups. Conclusion: Local usage of low dose methotrexate and tenoxicam may be helpful option for prevention of peridural fibrosis after laminectomy procedures in future. © 2015, Ege University Press. All rights reserved.en_US
dc.identifier.endpage538en_US
dc.identifier.issn1300-1817en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage528en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32778
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEge University Pressen_US
dc.relation.ispartofJournal of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLaminectomyen_US
dc.subjectMethotraxateen_US
dc.subjectPeridural fibrosisen_US
dc.subjectTenoxicamen_US
dc.titleProtective effects of methotrexate and tenoxicam in peridural fibrosis in rat laminectomy modelen_US
dc.title.alternativeSıçan laminektomi modelinde metotreksat ve tenoksikam ile epidural fibrozisin önlenmesi
dc.typeArticleen_US

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