Improving catalytic hydrolysis reaction efficiency of sol-gel-encapsulated Candida rugosa lipase with magnetic beta-cyclodextrin nanoparticles

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dc.contributor.authorÖzyılmaz, Elif
dc.contributor.authorSayın, Serkan
dc.contributor.authorArslan, Mustafa
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T18:51:04Z
dc.date.available2020-03-26T18:51:04Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractA silica-based p-cyclodextrin was immobilized on magnetic nanoparticles to obtain a macrocyclic compound with magnetic property. Then, the beta-cyclodextrin-grafted magnetic nanoparticles were encapsulated with Candida rugosa lipase in sol-gel matrices using alkoxysilane precursors. The catalytic activity of the encapsulated lipases was evaluated with model reactions, i.e., the hydrolysis of p-nitro-phenylpalmitate (p-NPP) and the enantioselective hydrolysis of rasemic Naproxen methyl ester that was studied in an aqueous buffer solution/isooctane reaction system. The results indicate that the cyclodextrin-based, encapsulated lipase particularly exhibited high conversion and enantioselectivity behavior compared to the sol-gel free lipase. It was also observed that excellent enantioselectivity (E=399) was obtained for the encapsulated lipase with magnetic beta-cyclodextrin that has an ee value of S-Naproxen acid of about 98%. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111T027]; Research Foundation of Selcuk University (BAP)Selcuk Universityen_US
dc.description.sponsorshipThe authors wish to acknowledge support from the Scientific and Technological Research Council of Turkey (TUBITAK grant no. 111T027) and The Research Foundation of Selcuk University (BAP) for financial support of this work.en_US
dc.identifier.doi10.1016/j.colsurfb.2013.08.019en_US
dc.identifier.endpage189en_US
dc.identifier.issn0927-7765en_US
dc.identifier.issn1873-4367en_US
dc.identifier.pmid24090713en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage182en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.colsurfb.2013.08.019
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30919
dc.identifier.volume113en_US
dc.identifier.wosWOS:000331670200023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofCOLLOIDS AND SURFACES B-BIOINTERFACESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLipaseen_US
dc.subjectCyclodextrinen_US
dc.subjectFe3O4en_US
dc.subjectEnantioselectivityen_US
dc.subjectDrugen_US
dc.titleImproving catalytic hydrolysis reaction efficiency of sol-gel-encapsulated Candida rugosa lipase with magnetic beta-cyclodextrin nanoparticlesen_US
dc.typeArticleen_US

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